SPG21

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPG21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SPG21 encodes maspardin, an ESCRT-associated protein involved in endosomal trafficking, autophagy, and neuroprotection. Mutations cause autosomal recessive hereditary spastic paraplegia (SPG21/Mast syndrome).

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graph TD
    SPG21["<b>SPG21</b>"]
    FYCO1["FYCO1"]
    SPG21 -->|"interacts with"| FYCO1
    TFEB["TFEB"]
    SPG21 -->|"regulates"| TFEB
    Mtor(["Mtor"])
    SPG21 -->|"interacts with"| Mtor
    SPG21 -->|"activates"| Mtor
    neurodegeneration["neurodegeneration"]
    SPG21 -->|"implicated in"| neurodegeneration
    RAB7["RAB7"]
    RAB7 -->|"regulates"| SPG21
    MTOR["MTOR"]
    MTOR -->|"interacts with"| SPG21
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"interacts with"| SPG21
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"interacts with"| SPG21
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| SPG21
    TFEB -->|"activates"| SPG21
    RAB7A["RAB7A"]
    RAB7A -->|"activates"| SPG21
    style SPG21 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0