RAB7

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RAB7 (RAB7, member RAS oncogene family) is a small GTPase critical for endolysosomal trafficking, autophagosome maturation, and lysosomal function. Mutations cause Charcot-Marie-Tooth disease type 2B. Dysfunction implicated in Alzheimer's disease, Parkinson's disease, and Huntington's disease.

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graph TD
    RAB7["<b>RAB7</b>"]
    Als{"Als"}
    RAB7 -->|"associated with"| Als
    Alzheimer{"Alzheimer"}
    RAB7 -->|"regulates"| Alzheimer
    Ms{"Ms"}
    RAB7 -->|"interacts with"| Ms
    Hepatitis{"Hepatitis"}
    RAB7 -->|"regulates"| Hepatitis
    RAB7 -->|"expressed in"| Alzheimer
    RAB7 -->|"regulates"| Ms
    Parkinson{"Parkinson"}
    RAB7 -->|"interacts with"| Parkinson
    RAB7 -->|"interacts with"| Alzheimer
    RAB7 -->|"interacts with"| Als
    ALS{"ALS"}
    RAB7 -->|"causes"| ALS
    RILP["RILP"]
    RAB7 -->|"activates"| RILP
    YAP["YAP"]
    RAB7 -->|"activates"| YAP
    NRBF2["NRBF2"]
    NRBF2 -->|"interacts with"| RAB7
    CCZ1_MON1A["CCZ1-MON1A"]
    CCZ1_MON1A -->|"activates"| RAB7
    NRBF2 -->|"activates"| RAB7
    IGF2R["IGF2R"]
    IGF2R -->|"associated with"| RAB7
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| RAB7
    RILP -->|"activates"| RAB7
    ATG14["ATG14"]
    ATG14 -->|"regulates"| RAB7
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RAB7
    YAP -->|"activates"| RAB7
    APP["APP"]
    APP -->|"regulates"| RAB7
    style RAB7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0