gene

SUST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

1Analyses

8Outgoing

0Incoming

Summary

SUMF1 - Sulfatase Modifying Factor 1

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🧬 Gene Info

Gene Symbol	SUMF1
Full Name	Sulfatase Modifying Factor 1
Aliases	Page for SUMF1 Protein
Chromosome	2q33.1
Function	The SUMF1 protein, also known as formylglycine-generating enzyme (FGE), catalyzes the conversion of a conserved cysteine residue to formylglycine (FGly) in the active site of all sulfatases.
Primary Expression	Brain, Liver, Kidney, Lung
Molecular Weight	42 kDa
Amino Acids	345 aa
Exons	9
Pathways	oxidative stress response
UniProt ID	Q8IWU6
NCBI Gene ID	285362
Ensembl ID	ENSG00000144455
OMIM	272300
GeneCards	SUMF1
Human Protein Atlas	SUMF1
Associated Diseases	Multiple Sulfatase Deficiency
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SUST["<b>SUST</b>"]
    GPR91["GPR91"]
    SUST -->|"associated with"| GPR91
    PP2C["PP2C"]
    SUST -->|"associated with"| PP2C
    HGF["HGF"]
    SUST -->|"associated with"| HGF
    MET["MET"]
    SUST -->|"associated with"| MET
    LZTR1["LZTR1"]
    SUST -->|"associated with"| LZTR1
    MAP2K1["MAP2K1"]
    SUST -->|"associated with"| MAP2K1
    RAF1["RAF1"]
    SUST -->|"associated with"| RAF1
    TP53["TP53"]
    SUST -->|"associated with"| TP53
    neurodegeneration["neurodegeneration"]
    SUST -->|"implicated in"| neurodegeneration
    style SUST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
GPR91	associated_with	receptor	0.80
PP2C	associated_with	gene	0.80
MET	associated_with	gene	0.70
MAP2K1	associated_with	gene	0.70
RAF1	associated_with	gene	0.70
HGF	associated_with	gene	0.70
LZTR1	associated_with	gene	0.70
TP53	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found