gene

RAF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

RAF1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, interacts with. Associated with Aging, Als, Anxiety. Connected to 128 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAF1
Full NameRAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)
Chromosome3p25.2
Protein TypeKinase
Functionencodes a 648-amino acid serine/threonine protein kinase with a molecular mass of approximately 72.
Primary Expressionbrain tissue
Amino Acids648 aa
PathwaysMAPK
UniProt ID[P04049](https://www.uniprot.org/uniprot/P04049)
Ensembl IDENSG00000132155
OMIM164760
GeneCardsRAF1
Human Protein AtlasRAF1
Apoptosis RegulationInteracts with BAD, caspase-9
Scaffold FunctionOrganizes signaling complexes
Associated DiseasesAls, Ms, Tumor
InteractionsCDC42, ACVR1, MDM2, EGF, P21, ERK1
KG Connections167 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)

gene · 1374 words

GNB4 Protein — G Protein Subunit Beta 4

protein · 2562 words

MAP2K2 Gene

gene · 2515 words

SUMF1 - Sulfatase Modifying Factor 1

gene · 2144 words

DIABLO

gene · 2135 words

RASA2 — RAS GTPase-Activating Protein 2

gene · 1711 words

Pathway Diagram

graph TD
    RAF1["RAF1"]
    RAF1 -->|"regulates"| Ms["Ms"]
    RAF1 -->|"regulates"| Stroke["Stroke"]
    RAF1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    RAF1 -->|"target for"| Diabetes["Diabetes"]
    RAF1 -->|"target for"| Obesity["Obesity"]
    RAF1 -->|"target for"| Als["Als"]
    RAF1 -->|"target for"| Hypertension["Hypertension"]
    RAF1 -->|"target for"| Ischemia["Ischemia"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| RAF1
    E2F1["E2F1"] -->|"regulates"| RAF1
    P53["P53"] -->|"regulates"| RAF1
    MYC["MYC"] -->|"regulates"| RAF1
    DIABLO["DIABLO"] -->|"regulates"| RAF1
    EGF["EGF"] -->|"activates"| RAF1
    ERK1["ERK1"] -->|"activates"| RAF1
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| RAF1
    MDM2["MDM2"] -->|"activates"| RAF1
    PI3K["PI3K"] -->|"target for"| RAF1

Outgoing (99)

TargetRelationTypeStr
Mapkactivatespathway0.90
Mapktherapeutic_targetpathway0.70
Msregulatesdisease0.65
Strokeregulatesdisease0.65
Neurodegenerationregulatesdisease0.65

Incoming (68)

SourceRelationTypeStr
SUSTassociated_withgene0.70
E2F1regulatesgene0.60
MYCregulatesgene0.60
DIABLOregulatesgene0.60
EGFactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found