Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAF1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, interacts with. Associated with Aging, Als, Anxiety. Connected to 128 entities in the SciDEX knowledge graph.
| Gene Symbol | RAF1 |
| Full Name | RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf) |
| Chromosome | 3p25.2 |
| Protein Type | Kinase |
| Function | encodes a 648-amino acid serine/threonine protein kinase with a molecular mass of approximately 72. |
| Primary Expression | brain tissue |
| Amino Acids | 648 aa |
| Pathways | MAPK |
| UniProt ID | [P04049](https://www.uniprot.org/uniprot/P04049) |
| Ensembl ID | ENSG00000132155 |
| OMIM | 164760 |
| GeneCards | RAF1 |
| Human Protein Atlas | RAF1 |
| Apoptosis Regulation | Interacts with BAD, caspase-9 |
| Scaffold Function | Organizes signaling complexes |
| Associated Diseases | Als, Ms, Tumor |
| Interactions | CDC42, ACVR1, MDM2, EGF, P21, ERK1 |
| KG Connections | 167 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAF1["RAF1"]
RAF1 -->|"regulates"| Ms["Ms"]
RAF1 -->|"regulates"| Stroke["Stroke"]
RAF1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
RAF1 -->|"target for"| Diabetes["Diabetes"]
RAF1 -->|"target for"| Obesity["Obesity"]
RAF1 -->|"target for"| Als["Als"]
RAF1 -->|"target for"| Hypertension["Hypertension"]
RAF1 -->|"target for"| Ischemia["Ischemia"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| RAF1
E2F1["E2F1"] -->|"regulates"| RAF1
P53["P53"] -->|"regulates"| RAF1
MYC["MYC"] -->|"regulates"| RAF1
DIABLO["DIABLO"] -->|"regulates"| RAF1
EGF["EGF"] -->|"activates"| RAF1
ERK1["ERK1"] -->|"activates"| RAF1
APOPTOSIS["APOPTOSIS"] -->|"regulates"| RAF1
MDM2["MDM2"] -->|"activates"| RAF1
PI3K["PI3K"] -->|"target for"| RAF1| Target | Relation | Type | Str |
|---|---|---|---|
| Mapk | activates | pathway | 0.90 |
| Mapk | therapeutic_target | pathway | 0.70 |
| Ms | regulates | disease | 0.65 |
| Stroke | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Stroke | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Hypertension | therapeutic_target | disease | 0.65 |
| Ischemia | therapeutic_target | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Lymphoma | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Anxiety | treats | disease | 0.65 |
| Depression | treats | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| P38 | regulates | gene | 0.60 |
| DYRK1A | regulates | gene | 0.60 |
| SMAC | regulates | gene | 0.60 |
| AIF | regulates | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| CREBBP | associated_with | gene | 0.60 |
| PIK3R1 | associated_with | gene | 0.60 |
| CHUK | therapeutic_target | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ACVR1 | interacts_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| JNK | regulates | gene | 0.60 |
| MDM2 | activates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| DIABLO | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| CREB1 | expressed_in | gene | 0.60 |
| MAPK3 | therapeutic_target | gene | 0.60 |
| MAPK1 | therapeutic_target | gene | 0.60 |
| PRKCD | therapeutic_target | gene | 0.60 |
| CDKN1A | therapeutic_target | gene | 0.60 |
| CDKN1B | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SUST | associated_with | gene | 0.70 |
| E2F1 | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| DIABLO | regulates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| MDM2 | activates | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| IGF1R | associated_with | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| AKT1 | associated_with | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| RXRA | associated_with | gene | 0.60 |
| HSP90AA1 | associated_with | gene | 0.60 |
| MAPK14 | associated_with | gene | 0.60 |
| MDM2 | associated_with | gene | 0.60 |
| RELA | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| PRKACA | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| PIK3CA | interacts_with | gene | 0.60 |
| RANKINGS | interacts_with | gene | 0.60 |
| RAC1 | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| CBL | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| RHOA | interacts_with | gene | 0.60 |
| TRAF2 | interacts_with | gene | 0.60 |
| TRAF6 | interacts_with | gene | 0.60 |
| TGFBR1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| MAP2K1 | associated_with | gene | 0.60 |
| ANGPT1 | associated_with | gene | 0.60 |
| RHOA | associated_with | gene | 0.60 |
| SCN8A | activates | gene | 0.60 |
| ERK1 | expressed_in | gene | 0.60 |
| BIRC5 | therapeutic_target | gene | 0.60 |
| NRAS | associated_with | gene | 0.60 |
| BRAF | associated_with | gene | 0.60 |
| CHUK | therapeutic_target | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| HMOX1 | regulates | gene | 0.60 |
| HSPA8 | regulates | gene | 0.60 |
| JAK1 | regulates | gene | 0.60 |
| JAK2 | regulates | gene | 0.60 |
| MAPK1 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||