gene

MET

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

636Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

Page for MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	MET
Aliases	Page for MET, c-Met
Chromosome	7q31.2
Protein Type	Receptor
Function	is a receptor tyrosine kinase (RTK) that plays crucial roles in embryonic development, tissue regeneration, and adult tissue homeostasis.
Molecular Weight	140 kDa
Amino Acids	1390 aa
Exons	21
Pathways	Key Effectors
GeneCards	MET
Human Protein Atlas	MET
Associated Diseases	AD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	metformin, PLB-1001, resveratrol
Interactions	AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	636 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MET["MET"] -->|"associated"| glioblastoma["glioblastoma"]
    MET["MET"] -->|"activates"| glioma_progression["glioma progression"]
    MET["MET"] -->|"biomarker for"| secondary_glioblastoma["secondary glioblastoma"]
    MET["MET"] -->|"therapeutic target"| Cancer["Cancer"]
    MET["MET"] -->|"expressed in"| Carcinoma["Carcinoma"]
    MET["MET"] -->|"therapeutic target"| Ms["Ms"]
    PTPRZ1["PTPRZ1"] -->|"interacts"| MET["MET"]
    PLB_1001["PLB-1001"] -.->|"inhibits"| MET["MET"]
    IDH1["IDH1"] -->|"therapeutic target"| MET["MET"]
    VEGFA["VEGFA"] -->|"therapeutic target"| MET["MET"]
    style MET fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (401)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
acquired resistance	promotes	phenotype	0.90
Alzheimer's Disease	downregulates	disease	0.85
Inflammation	therapeutic_target	disease	0.85
MET Signaling	regulates	pathway	0.85
Inflammation	associated_with	disease	0.85
Als	associated_with	disease	0.85
GSK3B	regulates	protein	0.80
Cancer	regulates	disease	0.75
Cancer	associated_with	disease	0.75
Carcinoma	activates	disease	0.75
Schizophrenia	associated_with	disease	0.75
Glioblastoma	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Infection	activates	disease	0.75
Stroke	therapeutic_target	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
Fibrosis	activates	disease	0.75
Depression	associated_with	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
endothelial cells	expressed_in	cell_type	0.75
Als	activates	disease	0.75
Tumor	regulates	disease	0.75
Neuroinflammation	therapeutic_target	disease	0.75
Parkinson	therapeutic_target	disease	0.75
Diabetes	therapeutic_target	disease	0.75
Mapk	regulates	pathway	0.70
Mapk	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Wnt signaling	participates_in	pathway	0.70
Stem Cell	therapeutic_target	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
glioblastoma	associated_with	disease	0.70
Oxidative Stress	associated_with	pathway	0.70
Apoptosis	activates	pathway	0.70
secondary glioblastoma	biomarker_for	disease	0.70
glioma progression	activates	process	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Autoimmune	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Schizophrenia	therapeutic_target	disease	0.65
Bipolar	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	biomarker_for	disease	0.65
Lymphoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65

Incoming (235)

Source	Relation	Type	Str
EGFR	interacts_with	gene	0.90
CANCER	therapeutic_target	gene	0.90
PI3K	activates	gene	0.90
Circular RNA	associated_with	process	0.80
AKT	activates	gene	0.80
EGFR	inhibits	gene	0.80
PLB-1001	inhibits	drug	0.70
CANCER	activates	gene	0.70
SUST	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
AKT	therapeutic_target	gene	0.70
CANCER	regulates	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
DEPRESSION	associated_with	gene	0.70
CANCER	associated_with	gene	0.70
STROKE	therapeutic_target	gene	0.70
INFLAMMATION	associated_with	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
PTPRZ1	interacts_with	gene	0.70
COMPLEMENT	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
DIABETES MELLITUS	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
RAS	treats	gene	0.60
GENES	treats	gene	0.60
STROKE	associated_with	gene	0.60
LZTR1	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
DENND3	therapeutic_target	gene	0.60
TAU	phosphorylates	gene	0.60
MEK	inhibits	gene	0.60
COMPLEMENT	regulates	gene	0.60
LC3B	inhibits	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
STROKE	biomarker_for	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
PD-1	inhibits	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
INS	associated_with	gene	0.60
INS	biomarker_for	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Colla	0.895	neurodegeneration	Which specific factors in conditioned me
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.895	neurodegeneration	What is the therapeutic window between i
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Prima	0.862	neurodegeneration	Variant Annotation and Prioritization of
TREM2 Deficiency Drives Microglial Senescence via Lipid Meta	0.836	neurodegeneration	What molecular mechanisms drive microgli

Ketone Utilization Index as Metabolic Flexibility Biomarker	0.829	translational-neuroscience	Which metabolic biomarkers can distingui
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.820	neurodegeneration	What is the therapeutic window between i
TREM2-mTOR Co-Agonism for Metabolic Reprogramming	0.803	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from E	0.770	neurodegeneration	Investigate mechanisms of epigenetic rep
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.769	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove	0.745	neurodegeneration	Epigenetic reprogramming in aging neuron
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.744	neurodegeneration	Gene expression changes in aging mouse b
Metabolic Inflexibility Precedes Transcriptional Reprogrammi	0.735	neurodegeneration	What is the optimal therapeutic window f
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.735	-	What blood-brain barrier permeability ch
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
Metabolic-Support Secretome Dysfunction	0.730	neurodegeneration	Which specific factors in conditioned me
Adenosine-Astrocyte Metabolic Reset	0.730	neurodegeneration	Sleep disruption as cause and consequenc
Metabolic Switch Targeting for A1→A2 Repolarization	0.726	neurodegeneration	Astrocyte reactivity subtypes in neurode
Interfacial Lipid Mimetics to Disrupt Domain Interaction	0.723	neurodegeneration	APOE4 structural biology and therapeutic
Regional TREM2-Dependent Lipid Metabolism Determines Cortica	0.721	neuroinflammation	How do regional, age, and sex-dependent
Metabolic Reprogramming to Reverse Senescence	0.720	-	Senescent cell clearance as neurodegener
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.718	alzheimers	TREM2 agonism vs antagonism in DAM micro
APOE4-Specific Microglial Metabolic Rescue	0.710	-	Neuroinflammation and microglial priming
Metabolic Circuit Breaker via Lipid Droplet Modulation	0.709	neurodegeneration	Microglia-astrocyte crosstalk amplificat
TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM	0.708	alzheimers	-
TET2-Mediated Demethylation Rejuvenation Therapy	0.706	neurodegeneration	Epigenetic clocks and biological aging i
Astrocyte-Neuron Metabolic Coupling Titration	0.704	metabolic-neuroscience	What determines the optimal timing and d
Gamma entrainment restores astrocyte-neuron metabolic coupli	0.700	alzheimers	Gamma entrainment therapy to restore hip
Metabolic Coupling Disruption Sensitizes Motor Neuron mPTP T	0.700	neurodegeneration	What determines the specificity of TDP-4

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
AECII-specific HMGCS2 overexpression in mouse pulmonary fibrosis	validation	idiopathic pulmonary fibrosis	0.950	C57BL/6 mice with AECII-specif	proposed	N/A
MAPK pathway inhibition by QTJD through butyrate mechanism	exploratory	Mycoplasma pneumoniae pneumoni	0.900	Mouse macrophages	proposed	N/A
NAD depletion effects on monocyte/macrophage differentiation	exploratory	Inflammatory bowel disease	0.900	Primary mouse and human monocy	proposed	N/A
FK866 treatment in DSS-induced colitis mouse model	validation	Inflammatory bowel disease (co	0.900	DSS-induced colitis mice	proposed	N/A
Ketogenic diet fat threshold analysis in wild-type mice	validation	metabolic disease	0.900	C57BL/6J wild-type mice	proposed	N/A
HMGCS2 gain-of-function in AECII lipid metabolism regulation	exploratory	idiopathic pulmonary fibrosis	0.900	human AECIIs	proposed	N/A
Ketogenic diet efficacy in diet-induced obese mice	validation	obesity, metabolic disease	0.900	C57BL/6J diet-induced obese mi	proposed	N/A
FK866 in azoxymethane/DSS colitis-associated cancer model	validation	Colitis-associated cancer	0.850	AOM/DSS-treated mice	proposed	N/A
FK866 mechanism validation in Rag1-/- mice	validation	Inflammatory bowel disease	0.850	Rag1-/- mice with DSS-induced	proposed	N/A
Microarray and single-cell RNA analysis of lipid metabolism genes	exploratory	idiopathic pulmonary fibrosis	0.850	human patients, mouse models	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808]	Acharya A, Ambikan AT, Neogi U, Lamberty	Res Sq	2026	0
Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475]	Dang TN, Ghosh B, Panta PR, Taylor JM, K	J Lipid Res	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroi [PMID:39930360]	Carrasco M, Guzman L, Olloquequi J, Cano	Molecular medicine (Cambridge,	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation [PMID:39744521]	["Wijesinghe Printha", "Li Hao Ran", "Ai	Frontiers in aging neuroscienc	2024	0
Pathological remodeling of reactive astrocytes: Involvement of DNA methylation a [PMID:38943350]	Cuautle DG, Donna S, Cieri MB, Villarrea	Journal of neurochemistry	2024	0
Trem2-deficiency aggravates and accelerates age-related myelin degeneration. [PMID:39300502]	["McCray Tyler J", "Bedford Logan M", "B	Acta neuropathologica communic	2024	0
SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928]	You Y, Liang W	Biochim Biophys Acta Mol Basis	2023	0
CD300f immune receptor contributes to healthy aging by regulating inflammaging, [PMID:37864797]	Evans F, Alí-Ruiz D, Rego N, Negro-Demon	Cell reports	2023	0
Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345]	Hussain R, Graham U, Elder A, Nedergaard	Trends in neurosciences	2023	0
Roles of neuropathology-associated reactive astrocytes: a systematic review. [PMID:36915214]	Lawrence JM, Schardien K, Wigdahl B, Non	Acta neuropathologica communic	2023	0
SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928]	You Y, Liang W	Biochimica et biophysica acta.	2023	0
Regulation of SIRT1 and Its Roles in Inflammation. [PMID:35359990]	Yang Y, Liu Y, Wang Y, Chao Y, Zhang J,	Frontiers in immunology	2022	0
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk f [PMID:36411364]	Holstege H, Hulsman M, Charbonnier C	Nat Genet	2022	0
The role of innate immune genes in Alzheimer's disease. [PMID:33560670]	Griciuc A, Tanzi RE	Curr Opin Neurol	2021	0
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020	0
SIRT1 and aging related signaling pathways. [PMID:32084459]	Chen C, Zhou M, Ge Y, Wang X	Mechanisms of ageing and devel	2020	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MET in their description or question text

Ketone Utilization Index as Metabolic Flexibility Biomarker

Score: 0.829 · translational-neuroscience · 2026-04-16

## Mechanistic Overview Ketone Utilization Index as Metabolic Flexibility Biomarker starts from the claim that modulatin

HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase

Score: 0.820 · neurodegeneration · 2026-04-13

## Mechanistic Overview HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation start

TREM2-mTOR Co-Agonism for Metabolic Reprogramming

Score: 0.803 · neurodegeneration · 2026-04-16

## Mechanistic Overview TREM2-mTOR Co-Agonism for Metabolic Reprogramming starts from the claim that modulating TREM2-mT

H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasi

Score: 0.770 · neurodegeneration · 2026-04-22

## Mechanistic Overview H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasis starts from th

METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Sequestration

Score: 0.769 · molecular-neurobiology · 2026-04-17

## **Molecular Mechanism and Rationale** The methyltransferase-like 3 (METTL3) enzyme functions as the catalytic subuni

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming

Score: 0.748 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The TREM2-CSF1R metabolic cross-talk hypothesis centers on the intricate molecula

Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression

Score: 0.745 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The NAD+ salvage pathway represents a critical metabolic hub in neuronal energy h

TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging

Score: 0.744 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The TREM2-SIRT1 metabolic senescence circuit represents a critical regulatory net

Metabolic Inflexibility Precedes Transcriptional Reprogramming (NAD+/SIRT3 Axis)

Score: 0.735 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The NAD+/SIRT3 axis represents a critical regulatory hub controlling mitochondria

Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Blood as an Early Indi

Score: 0.735 · unknown disease · 2026-04-26

Elevated MMP-9/TIMP-1 ratio reflects net proteolytic activity against the BBB, causing degradation of tight junction pro

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

Score: 0.733 · molecular-neurobiology · 2026-04-17

**Molecular Mechanism and Rationale** The lncRNA-0021/miR-6361 interaction represents a sophisticated regulatory mechan

Metabolic-Support Secretome Dysfunction

Score: 0.730 · neurodegeneration · 2026-04-25

Healthy astrocytes provide a balanced fuel/redox/pH composition (including lactate, glucose, pyruvate, and NAD+/NADH-rel

Adenosine-Astrocyte Metabolic Reset

Score: 0.730 · neurodegeneration · 2026-04-02

## Mechanistic Overview Adenosine-Astrocyte Metabolic Reset starts from the claim that modulating ADORA2A within the dis

Metabolic Switch Targeting for A1→A2 Repolarization

Score: 0.726 · neurodegeneration · 2026-04-02

## Mechanistic Overview Metabolic Switch Targeting for A1→A2 Repolarization starts from the claim that modulating HK2 wi

Interfacial Lipid Mimetics to Disrupt Domain Interaction

Score: 0.723 · neurodegeneration · 2026-04-02

## Mechanistic Overview Interfacial Lipid Mimetics to Disrupt Domain Interaction starts from the claim that modulating A

MET