Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUZ12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SUZ12 |
| Full Name | SUZ12 Polycomb Repressive Complex 2 Subunit |
| Chromosome | 17q11.2 |
| Function | encodes an essential zinc finger-containing subunit of Polycomb Repressive Complex 2 (PRC2). |
| Amino Acids | 739 aa |
| Pathways | Mtor |
| UniProt ID | Q15022 |
| Ensembl ID | ENSG00000178691 |
| OMIM | 606245 |
| GeneCards | SUZ12 |
| Human Protein Atlas | SUZ12 |
| Associated Diseases | neurodegeneration |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SUZ12"]
N1["Cancer"]
N0 -->|"regulates"| N1
N2["Als"]
N0 -->|"regulates"| N2
N3["MTOR"]
N0 -->|"regulates"| N3
N4["Mtor"]
N0 -->|"regulates"| N4
N5["PI3K"]
N5 -->|"regulates"| N0
N6["CANCER"]
N6 -->|"regulates"| N0
N7["AKT"]
N7 -->|"regulates"| N0
N8["DNA"]
N8 -->|"regulates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 pathway
class N5 gene
class N6 gene
class N7 gene
class N8 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SUZ12 in their description or question text
No additional research found