Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sleep Deprivation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Sleep Deprivation |
| Related Diseases | ALZHEIMER'S DISEASE, Brain Alterations, Microglial Reactivity, Cognitive Impairments, Seizures |
| Related Pathways | Convergent Brain Alterations, Metabolic Dyshomeostasis |
Knowledge base pages for this entity
graph TD
Sleep_Deprivation["Sleep Deprivation"] -->|"causes"| Brain_Alterations["Brain Alterations"]
style Brain_Alterations fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"causes"| Microglial_Reactivity["Microglial Reactivity"]
style Microglial_Reactivity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"risk factor for"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"causes"| Neuroinflammation["Neuroinflammation"]
style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"causes"| Cognitive_Impairments["Cognitive Impairments"]
style Cognitive_Impairments fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"causes"| Amyloid_Beta_Deposition["Amyloid-Beta Deposition"]
style Amyloid_Beta_Deposition fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Sleep_Deprivation["Sleep Deprivation"] -->|"involved in"| Convergent_Brain_Alterations["Convergent Brain Alterations"]
style Convergent_Brain_Alterations fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Sleep_Disorders["Sleep Disorders"] -->|"associated"| Sleep_Deprivation["Sleep Deprivation"]
style Sleep_Disorders fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Brain_Alterations_1["Brain Alterations"] -->|"biomarker for"| Sleep_Deprivation["Sleep Deprivation"]
style Brain_Alterations_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
style Sleep_Deprivation fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | risk_factor_for | disease | 0.95 |
| Brain Alterations | causes | phenotype | 0.95 |
| Microglial Reactivity | causes | phenotype | 0.95 |
| Neuroinflammation | causes | process | 0.95 |
| Cognitive Impairments | causes | phenotype | 0.95 |
| Seizures | promotes | phenotype | 0.95 |
| Pentylenetetrazol-Induced Seizures | associated_with | phenotype | 0.95 |
| Amyloid-Beta Deposition | causes | phenotype | 0.92 |
| Amyloid-Beta Plaque Deposition | causes | phenotype | 0.92 |
| Convergent Brain Alterations | involved_in | mechanism | 0.90 |
| Alzheimer's Disease | risk_factor_for | disease | 0.90 |
| Cognitive Decline | risk_factor_for | phenotype | 0.88 |
| Metabolic Dyshomeostasis | causes | mechanism | 0.88 |
| Lysosomal Maturation | associated_with | process | 0.85 |
| Neurotoxic Waste Accumulation | causes | phenotype | 0.85 |
| Lysosomal Maturation | inhibits | phenotype | 0.85 |
| BDNF | downregulates | protein | 0.85 |
| Anxiety-Related Behaviors | associated_with | phenotype | 0.85 |
| Corticosterone | upregulates | compound | 0.85 |
| Neuro-Immune Cross-Talk | modulates | process | 0.80 |
| Brain Plasticity | modulates | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GHYSJ | treats | drug | 0.95 |
| Sleep Disorders | associated_with | disease | 0.85 |
| Brain Alterations | biomarker_for | phenotype | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||