Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about glymphatic clearance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | glymphatic clearance |
| Key Genes/Proteins | AQP4, PS1, ALS, APOE, APOE4 |
| Related Diseases | Alzheimer's disease, neurodegeneration, neuroinflammation, traumatic brain injury |
| Linked Hypotheses | 9 hypotheses |
Knowledge base pages for this entity
graph TD
glymphatic_clearance["glymphatic clearance"] -->|"active in"| astrocytes["astrocytes"]
style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glymphatic_clearance["glymphatic clearance"] -->|"active in"| cortex["cortex"]
style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glymphatic_clearance["glymphatic clearance"] -->|"active in"| macrophages["macrophages"]
style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glymphatic_clearance["glymphatic clearance"] -->|"active in"| blood_brain_barrier["blood-brain barrier"]
style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glymphatic_clearance["glymphatic clearance"] -->|"active in"| endothelial_cells["endothelial cells"]
style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glymphatic_clearance["glymphatic clearance"] -->|"active in"| dopaminergic_neurons["dopaminergic neurons"]
style dopaminergic_neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AQP4["AQP4"] -->|"participates in"| glymphatic_clearance["glymphatic clearance"]
style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neuroinflammation["neuroinflammation"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
traumatic_brain_injury["traumatic brain injury"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
style traumatic_brain_injury fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style glymphatic_clearance fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| astrocytes | active_in | cell_type | 0.80 |
| cortex | active_in | brain_region | 0.60 |
| macrophages | active_in | cell_type | 0.60 |
| blood-brain barrier | active_in | brain_region | 0.60 |
| endothelial cells | active_in | cell_type | 0.60 |
| dopaminergic neurons | active_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AQP4 | participates_in | gene | 0.90 |
| Alzheimer's disease | involves | disease | 0.90 |
| neurodegeneration | involves | disease | 0.80 |
| PS1 | participates_in | gene | 0.75 |
| astrocytes | active_in | cell_type | 0.75 |
| neuroinflammation | involves | disease | 0.70 |
| ALS | participates_in | gene | 0.70 |
| APOE | participates_in | gene | 0.65 |
| APOE4 | participates_in | gene | 0.65 |
| traumatic brain injury | involves | disease | 0.60 |
| ERK1 | participates_in | gene | 0.60 |
| stroke | involves | disease | 0.60 |
| APP | participates_in | gene | 0.60 |
| RNA | participates_in | gene | 0.60 |
| GFAP | participates_in | gene | 0.60 |
| MAPK signaling | crosstalk_with | pathway | 0.60 |
| MAPK | participates_in | gene | 0.60 |
| Parkinson's disease | involves | disease | 0.60 |
| PERK | participates_in | gene | 0.60 |
| CK2 | participates_in | gene | 0.60 |
| CCR2 | participates_in | gene | 0.60 |
| ATP | participates_in | gene | 0.60 |
| LRRK2 | participates_in | gene | 0.60 |
| multiple sclerosis | involves | disease | 0.60 |
| ATXN3 | participates_in | gene | 0.60 |
| SCA3 | participates_in | gene | 0.60 |
| CD36 | participates_in | gene | 0.60 |
| GBA | participates_in | gene | 0.60 |
| GABA | participates_in | gene | 0.60 |
| P2Y12 | participates_in | gene | 0.60 |
| epilepsy | involves | disease | 0.60 |
| glioblastoma | involves | disease | 0.60 |
| LOX | participates_in | gene | 0.55 |
| DDC | participates_in | gene | 0.55 |
| ROS | participates_in | gene | 0.55 |
| inhibitory neurons | active_in | cell_type | 0.55 |
| PDGFR | participates_in | gene | 0.55 |
| TREK-1 | participates_in | gene | 0.55 |
| rapamycin | modulates | drug | 0.55 |
| GABRA1 | participates_in | gene | 0.55 |
| neurons | active_in | cell_type | 0.55 |
| AQP1 | participates_in | gene | 0.55 |
| frontotemporal dementia | involves | disease | 0.55 |
| ALS | involves | disease | 0.55 |
| tauopathy | involves | disease | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||