gene

TBX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

8Outgoing

4Incoming

Summary

TBX3 (T-Box Transcription Factor 3) - developmental transcription factor with roles in stem cell maintenance and neurodegeneration

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🧬 Gene Info

Gene Symbol	TBX3
Full Name	T-Box Transcription Factor 3
Chromosome	12q24.21
Protein Type	Transcription Factor
Function	is a member of the T-box family of transcription factors that play critical roles in embryonic development, tissue patterning, and stem cell biology.
Primary Expression	multiple brain regions during development and in adulthood, with particular importance in neural stem cell populations
Amino Acids	723 aa
Pathways	Epigenetic, Necroptosis
UniProt ID	O15147
NCBI Gene ID	6906
Ensembl ID	ENSG00000129932
OMIM	601400
GeneCards	TBX3
Human Protein Atlas	TBX3
Associated Diseases	neurodegeneration
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TBX3 — AlphaFold O15147 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TBX3["<b>TBX3</b>"]
    Als{"Als"}
    TBX3 -->|"regulates"| Als
    TCF3["TCF3"]
    TBX3 -->|"regulates"| TCF3
    neurodegeneration["neurodegeneration"]
    TBX3 -->|"implicated in"| neurodegeneration
    MYC["MYC"]
    MYC -->|"regulates"| TBX3
    CDK9["CDK9"]
    CDK9 -->|"regulates"| TBX3
    style TBX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
TCF3	regulates	gene	0.60
Epigenetic	regulates	pathway	0.60
Necroptosis	regulates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
MYC	regulates	gene	0.60
CDK9	regulates	gene	0.60
CANCER	regulates	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TBX3

Understanding Entity Pages

Summary

Wiki Pages (5)

TBX3 Gene

Parabrachial Complex

Limbic Thalamus Neurons