gene

UBE2D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBE2D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
0Hypotheses
0Analyses
11Outgoing
1Incoming

Summary

UBE2D1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolUBE2D1
Full NameUbiquitin-Conjugating Enzyme E2 D1
Chromosome10p11.21
Protein TypeEnzyme
FunctionUBE2D1 (Ubiquitin-Conjugating Enzyme E2 D1) is a member of the ubiquitin-conjugating enzyme family that functions as an E2 ubiquitin-conjugating enzyme in the ubiquitin-proteasome system.
Primary Expressionvarious cancers; regulates tumor suppressors and oncoproteins
PathwaysNF-κB, Wnt
UniProt IDP51668
NCBI Gene ID7329
Ensembl IDENSG00000100994
GeneCardsUBE2D1
Human Protein AtlasUBE2D1
Associated DiseasesAls, Ms
KG Connections12 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: UBE2D1 — AlphaFold P51668 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

UBE2D1

gene · 613 words

HERC4 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4)

gene · 2409 words

TRIM25 Gene (Tripartite Motif Containing 25)

gene · 2027 words

MARCHF1

gene · 1302 words

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

gene · 1197 words

Genes

index · 271 words

Pathway Diagram

graph TD
    UBE2D1["<b>UBE2D1</b>"]
    Als{"Als"}
    UBE2D1 -->|"associated with"| Als
    Ms{"Ms"}
    UBE2D1 -->|"associated with"| Ms
    LGALS1["LGALS1"]
    UBE2D1 -->|"associated with"| LGALS1
    CALCOCO2["CALCOCO2"]
    UBE2D1 -->|"associated with"| CALCOCO2
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    UBE2D1 -->|"associated with"| IMMUNE_INFILTRATION
    AUTOPHAGY["AUTOPHAGY"]
    UBE2D1 -->|"associated with"| AUTOPHAGY
    CDKN1A["CDKN1A"]
    UBE2D1 -->|"associated with"| CDKN1A
    NPC1["NPC1"]
    UBE2D1 -->|"associated with"| NPC1
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    UBE2D1 -->|"associated with"| AUTOPHAGY_RELATED_GENES
    Autophagy(["Autophagy"])
    UBE2D1 -->|"associated with"| Autophagy
    Mitochondrial_Function(["Mitochondrial Function"])
    UBE2D1 -->|"associated with"| Mitochondrial_Function
    neurodegeneration["neurodegeneration"]
    UBE2D1 -->|"implicated in"| neurodegeneration
    SCARB2["SCARB2"]
    SCARB2 -->|"associated with"| UBE2D1
    style UBE2D1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
LGALS1associated_withgene0.60
CALCOCO2associated_withgene0.60
CDKN1Aassociated_withgene0.60

Incoming (1)

SourceRelationTypeStr
SCARB2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found