Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE2D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UBE2D1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | UBE2D1 |
| Full Name | Ubiquitin-Conjugating Enzyme E2 D1 |
| Chromosome | 10p11.21 |
| Protein Type | Enzyme |
| Function | UBE2D1 (Ubiquitin-Conjugating Enzyme E2 D1) is a member of the ubiquitin-conjugating enzyme family that functions as an E2 ubiquitin-conjugating enzyme in the ubiquitin-proteasome system. |
| Primary Expression | various cancers; regulates tumor suppressors and oncoproteins |
| Pathways | NF-κB, Wnt |
| UniProt ID | P51668 |
| NCBI Gene ID | 7329 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | UBE2D1 |
| Human Protein Atlas | UBE2D1 |
| Associated Diseases | Als, Ms |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
UBE2D1["<b>UBE2D1</b>"]
Als{"Als"}
UBE2D1 -->|"associated with"| Als
Ms{"Ms"}
UBE2D1 -->|"associated with"| Ms
LGALS1["LGALS1"]
UBE2D1 -->|"associated with"| LGALS1
CALCOCO2["CALCOCO2"]
UBE2D1 -->|"associated with"| CALCOCO2
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
UBE2D1 -->|"associated with"| IMMUNE_INFILTRATION
AUTOPHAGY["AUTOPHAGY"]
UBE2D1 -->|"associated with"| AUTOPHAGY
CDKN1A["CDKN1A"]
UBE2D1 -->|"associated with"| CDKN1A
NPC1["NPC1"]
UBE2D1 -->|"associated with"| NPC1
AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
UBE2D1 -->|"associated with"| AUTOPHAGY_RELATED_GENES
Autophagy(["Autophagy"])
UBE2D1 -->|"associated with"| Autophagy
Mitochondrial_Function(["Mitochondrial Function"])
UBE2D1 -->|"associated with"| Mitochondrial_Function
neurodegeneration["neurodegeneration"]
UBE2D1 -->|"implicated in"| neurodegeneration
SCARB2["SCARB2"]
SCARB2 -->|"associated with"| UBE2D1
style UBE2D1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| LGALS1 | associated_with | gene | 0.60 |
| CALCOCO2 | associated_with | gene | 0.60 |
| CDKN1A | associated_with | gene | 0.60 |
| NPC1 | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AUTOPHAGY-RELATED GENES | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Mitochondrial Function | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SCARB2 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||