concept

SCARB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCARB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SCARB2 Gene
Summary	Page for SCARB2 Gene
Key Genes/Proteins	MTOR, ARF1
Related Diseases	Alpha-Synuclein Neurotoxicity, α-synuclein neurotoxicity, REM sleep behavior disorder, Retinal Degeneration, Ms

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SCARB2["SCARB2"]
    SCARB2 -->|"regulates"| MTOR["MTOR"]
    SCARB2 -->|"interacts"| ARF1["ARF1"]
    SCARB2 -->|"activates"| Obesity["Obesity"]
    SCARB2 -->|"activates"| Cancer["Cancer"]
    SCARB2 -->|"interacts"| Tumor["Tumor"]
    SCARB2 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SCARB2 -->|"activates"| Als["Als"]
    SCARB2 -->|"activates"| Aging["Aging"]
    Glutathione["Glutathione"] -->|"binds"| SCARB2
    SNCA["SNCA"] -->|"expressed in"| SCARB2
    MTORC1["MTORC1"] -->|"activates"| SCARB2
    CANCER["CANCER"] -->|"activates"| SCARB2
    MTOR -->|"activates"| SCARB2
    AND["AND"] -->|"interacts"| SCARB2
    ARF1 -->|"activates"| SCARB2
    GSH["GSH"] -->|"interacts"| SCARB2

Outgoing (61)

Target	Relation	Type	Str
MTOR	regulates	protein	0.90
ARF1	interacts_with	protein	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.80
REM sleep behavior disorder	associated_with	disease	0.70
Retinal Degeneration	activates	disease	0.65
Ms	associated_with	disease	0.65
Synucleinopathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Lewy Body	activates	disease	0.65
ALS	activates	disease	0.65
SNCA-AS1	expressed_in	gene	0.60
TMEM175	associated_with	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
NPC1	associated_with	gene	0.60
ARF1	activates	gene	0.60
GCLC	activates	gene	0.60
LIPA	activates	gene	0.60
SLC17A5	activates	gene	0.60
GNPTAB	activates	gene	0.60
SMPD1	activates	gene	0.60
NPC1	activates	gene	0.60
GBA	activates	gene	0.60
CTSD	activates	gene	0.60
MTOR	activates	gene	0.60
Rb	interacts_with	protein	0.60
Rb	activates	protein	0.60
TFAM	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
UCHL1	interacts_with	gene	0.60
SNCA	targets	gene	0.60
TMEM175	targets	gene	0.60
VPS13C	targets	gene	0.60
INPP5F	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mitochondrial Function	associated_with	pathway	0.60
Mtor	activates	pathway	0.60

Incoming (37)

Source	Relation	Type	Str
Glutathione	binds	compound	0.90
SNCA	expressed_in	gene	0.60
GBA	associated_with	gene	0.60
MTOR	activates	gene	0.60
ARF1	activates	gene	0.60
SMPD1	activates	gene	0.60
SLC17A5	activates	gene	0.60
NPC1	activates	gene	0.60
LIPA	activates	gene	0.60
CTSD	activates	gene	0.60
GNPTAB	activates	gene	0.60
GBA	activates	gene	0.60
A2M	interacts_with	gene	0.60
BCHE	interacts_with	gene	0.60
CHRFAM7A	interacts_with	gene	0.60
CNTN1	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
GABRB3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
BAG3	targets	gene	0.60
GBA1	targets	gene	0.60
LRRK2	targets	gene	0.60
RIT2	targets	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
AND	interacts_with	gene	0.60
GSH	interacts_with	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
GSH	targets	gene	0.60
GSH	associated_with	gene	0.60
DNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SCARB2

Understanding Entity Pages

Wiki Pages (21)

SCARB2 Gene

gba

msa-pathophysiology-disease-mechanisms

MSA Genetics and Risk Factors

msa-oligodendrocyte-pathology

rem-sleep-behavior-disorder

Endosomal-Lysosomal Pathway in Neurodegeneration

Multiple System Atrophy

Progressive Myoclonic Epilepsies (PME)

GABRB3 Gene

GBA and Lysosomal Function in Parkinson's Disease

MicroRNA Therapy for Parkinson's Disease

LIMP-2 Protein

gba-gene-therapy

LIMP-2 Protein

GNPTAB — N-Acetylglucosamine-1-Phosphate Transferase Alpha/Beta

Glial Cytoplasmic Inclusions in Multiple System Atrophy

RIT2 — Ras-Like Without CAAX 2 (Rin)

MDS 2026 — PD Genetic and Molecular Mechanisms