concept

SCARB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCARB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

0Hypotheses

1Analyses

50Outgoing

35Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SCARB2
Key Genes/Proteins	A2M, Actin, AGING, ALPHA-SYNUCLEIN, ARF1, AUTOPHAGY
Related Diseases	Aging, Alpha-Synuclein Neurotoxicity, Als, ALS
Related Pathways	Alpha-Synuclein, Autophagy

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SCARB2 Gene

gene · 863 words

→

Pathway Diagram

graph TD
    SCARB2["SCARB2"]
    SCARB2 -->|"regulates"| MTOR["MTOR"]
    SCARB2 -->|"interacts"| ARF1["ARF1"]
    SCARB2 -->|"activates"| Obesity["Obesity"]
    SCARB2 -->|"activates"| Cancer["Cancer"]
    SCARB2 -->|"interacts"| Tumor["Tumor"]
    SCARB2 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SCARB2 -->|"activates"| Als["Als"]
    SCARB2 -->|"activates"| Aging["Aging"]
    Glutathione["Glutathione"] -->|"binds"| SCARB2
    SNCA["SNCA"] -->|"expressed in"| SCARB2
    MTORC1["MTORC1"] -->|"activates"| SCARB2
    CANCER["CANCER"] -->|"activates"| SCARB2
    MTOR -->|"activates"| SCARB2
    AND["AND"] -->|"interacts"| SCARB2
    ARF1 -->|"activates"| SCARB2
    GSH["GSH"] -->|"interacts"| SCARB2

Outgoing (62)

Target	Relation	Type	Str
MTOR	regulates	protein	0.90
ARF1	interacts_with	protein	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.80
REM sleep behavior disorder	associated_with	disease	0.70
GBA lysosomal delivery	regulates	process	0.70
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Synucleinopathy	associated_with	disease	0.65
Obesity	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Retinal Degeneration	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
Lewy Body	activates	disease	0.65
Als	associated_with	disease	0.65
SLC17A5	activates	gene	0.60
GNPTAB	activates	gene	0.60
SMPD1	activates	gene	0.60
NPC1	activates	gene	0.60
GBA	activates	gene	0.60
CTSD	activates	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
LIPA	activates	gene	0.60
Mitochondrial Function	associated_with	pathway	0.60
AGING	activates	gene	0.60
Cholesterol	activates	pathway	0.60
PARKINSON	activates	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
NPC1	associated_with	gene	0.60
MTOR	activates	gene	0.60
Rb	interacts_with	protein	0.60
TFAM	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
UCHL1	interacts_with	gene	0.60
GSH	interacts_with	gene	0.60
Α-Synuclein	activates	protein	0.60
SNCA-AS1	expressed_in	gene	0.60
TMEM175	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MTORC1	activates	gene	0.60

Incoming (35)

Source	Relation	Type	Str
Glutathione	binds	compound	0.90
A2M	interacts_with	gene	0.60
BCHE	interacts_with	gene	0.60
CHRFAM7A	interacts_with	gene	0.60
CNTN1	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
GABRB3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
BAG3	targets	gene	0.60
GBA1	targets	gene	0.60
LRRK2	targets	gene	0.60
RIT2	targets	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
GSH	targets	gene	0.60
GNPTAB	activates	gene	0.60
GBA	activates	gene	0.60
SNCA	expressed_in	gene	0.60
GBA	associated_with	gene	0.60
MTOR	activates	gene	0.60
ARF1	activates	gene	0.60
SMPD1	activates	gene	0.60
SLC17A5	activates	gene	0.60
NPC1	activates	gene	0.60
LIPA	activates	gene	0.60
CTSD	activates	gene	0.60
GSH	interacts_with	gene	0.60
GSH	associated_with	gene	0.60
DNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning SCARB2 in their description or question text

No additional research found