Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LGALS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LGALS1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Ataxia, Cancer. Connected to 53 entities in the SciDEX knowledge graph.
| Gene Symbol | LGALS1 |
| Full Name | Galectin-1 |
| Chromosome | 22q13.1 |
| Function | LGALS1 performs diverse biological functions: |
| Amino Acids | 135 aa |
| Pathways | Mapk |
| GeneCards | LGALS1 |
| Human Protein Atlas | LGALS1 |
| Cell Type | Expression Level |
| [Neurons](/entities/neurons) | High (specific subtypes) |
| [Astrocytes](/entities/astrocytes) | High |
| [Microglia](/entities/microglia) | Moderate |
| Schwann Cells | High |
| Immune Cells | Variable |
| Model | Findings |
| Associated Diseases | Als, Ms |
| Interactions | JAK2, GNB4, HSP90B1, EGFR, HSPA4, FOXO1 |
| KG Connections | 89 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LGALS1["<b>LGALS1</b>"]
Als{"Als"}
LGALS1 -->|"associated with"| Als
Ms{"Ms"}
LGALS1 -->|"associated with"| Ms
Tumor{"Tumor"}
LGALS1 -->|"expressed in"| Tumor
Senescence{"Senescence"}
LGALS1 -->|"expressed in"| Senescence
Cancer{"Cancer"}
LGALS1 -->|"expressed in"| Cancer
Ataxia{"Ataxia"}
LGALS1 -->|"expressed in"| Ataxia
CALCOCO2["CALCOCO2"]
LGALS1 -->|"associated with"| CALCOCO2
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
LGALS1 -->|"associated with"| IMMUNE_INFILTRATION
AUTOPHAGY["AUTOPHAGY"]
LGALS1 -->|"associated with"| AUTOPHAGY
CDKN1A["CDKN1A"]
LGALS1 -->|"associated with"| CDKN1A
NPC1["NPC1"]
LGALS1 -->|"associated with"| NPC1
AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
LGALS1 -->|"associated with"| AUTOPHAGY_RELATED_GENES
SCARB2["SCARB2"]
SCARB2 -->|"associated with"| LGALS1
UBE2D1["UBE2D1"]
UBE2D1 -->|"associated with"| LGALS1
style LGALS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Senescence | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Ataxia | expressed_in | disease | 0.65 |
| Melanoma | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Colorectal Cancer | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ischemia | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Stroke | inhibits | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| CALCOCO2 | associated_with | gene | 0.60 |
| CDKN1A | associated_with | gene | 0.60 |
| NPC1 | associated_with | gene | 0.60 |
| P4HB | associated_with | gene | 0.60 |
| MT2A | associated_with | gene | 0.60 |
| TERT | expressed_in | gene | 0.60 |
| CFL1 | associated_with | gene | 0.60 |
| ATM | expressed_in | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| GNB4 | activates | gene | 0.60 |
| GPNMB | expressed_in | gene | 0.60 |
| GAIN | expressed_in | gene | 0.60 |
| FASN | regulates | gene | 0.60 |
| CDK1 | regulates | gene | 0.60 |
| CTSB | regulates | gene | 0.60 |
| CTSD | regulates | gene | 0.60 |
| ATG7 | expressed_in | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AUTOPHAGY-RELATED GENES | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Mitochondrial Function | associated_with | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| PTGS1 | regulates | gene | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| Wnt | therapeutic_target | pathway | 0.60 |
| Stem Cell | therapeutic_target | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SCARB2 | associated_with | gene | 0.60 |
| UBE2D1 | associated_with | gene | 0.60 |
| HSP90B1 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| HSPA4 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| HSP90AA1 | activates | gene | 0.60 |
| PRKACB | activates | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| IGF1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| QSOX1 | activates | gene | 0.60 |
| LAMB2 | activates | gene | 0.60 |
| WNT4 | activates | gene | 0.60 |
| LGALS3 | expressed_in | gene | 0.60 |
| CD44 | expressed_in | gene | 0.60 |
| SESN3 | expressed_in | gene | 0.60 |
| ATG7 | expressed_in | gene | 0.60 |
| CSF1R | expressed_in | gene | 0.60 |
| ALDH2 | regulates | gene | 0.60 |
| TARDBP | regulates | gene | 0.60 |
| GPNMB | expressed_in | gene | 0.60 |
| GAIN | expressed_in | gene | 0.60 |
| DIABETES MELLITUS | regulates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| MICROGLIA | expressed_in | gene | 0.60 |
| STROKE | inhibits | gene | 0.60 |
| LDHA | regulates | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| ACAT1 | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||