gene

LGALS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections
0Hypotheses
0Analyses
50Outgoing
36Incoming

Summary

LGALS1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Ataxia, Cancer. Connected to 53 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolLGALS1
Full NameGalectin-1
Chromosome22q13.1
FunctionLGALS1 performs diverse biological functions:
Amino Acids135 aa
PathwaysMapk
GeneCardsLGALS1
Human Protein AtlasLGALS1
Cell TypeExpression Level
[Neurons](/entities/neurons)High (specific subtypes)
[Astrocytes](/entities/astrocytes)High
[Microglia](/entities/microglia)Moderate
Schwann CellsHigh
Immune CellsVariable
ModelFindings
Associated DiseasesAls, Ms
InteractionsJAK2, GNB4, HSP90B1, EGFR, HSPA4, FOXO1
KG Connections89 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

LGALS1 — Galectin-1

gene · 670 words

QSOX1 Gene

gene · 1291 words

LGALS1 Protein — Galectin-1

protein · 740 words

CFL1 Gene

gene · 718 words

UBE2D1

gene · 613 words

SESN3 Gene

gene · 610 words

Pathway Diagram

graph TD
    LGALS1["<b>LGALS1</b>"]
    Als{"Als"}
    LGALS1 -->|"associated with"| Als
    Ms{"Ms"}
    LGALS1 -->|"associated with"| Ms
    Tumor{"Tumor"}
    LGALS1 -->|"expressed in"| Tumor
    Senescence{"Senescence"}
    LGALS1 -->|"expressed in"| Senescence
    Cancer{"Cancer"}
    LGALS1 -->|"expressed in"| Cancer
    Ataxia{"Ataxia"}
    LGALS1 -->|"expressed in"| Ataxia
    CALCOCO2["CALCOCO2"]
    LGALS1 -->|"associated with"| CALCOCO2
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    LGALS1 -->|"associated with"| IMMUNE_INFILTRATION
    AUTOPHAGY["AUTOPHAGY"]
    LGALS1 -->|"associated with"| AUTOPHAGY
    CDKN1A["CDKN1A"]
    LGALS1 -->|"associated with"| CDKN1A
    NPC1["NPC1"]
    LGALS1 -->|"associated with"| NPC1
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    LGALS1 -->|"associated with"| AUTOPHAGY_RELATED_GENES
    SCARB2["SCARB2"]
    SCARB2 -->|"associated with"| LGALS1
    UBE2D1["UBE2D1"]
    UBE2D1 -->|"associated with"| LGALS1
    style LGALS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Tumorexpressed_indisease0.65
Senescenceexpressed_indisease0.65
Cancerexpressed_indisease0.65

Incoming (36)

SourceRelationTypeStr
SCARB2associated_withgene0.60
UBE2D1associated_withgene0.60
HSP90B1activatesgene0.60
PI3Kregulatesgene0.60
EGFRactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found