protein

AIM2 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIM2 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

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0Incoming

0Experiments

0Debates

Summary

AIM2 is a cytosolic DNA sensor that forms the AIM2 inflammasome, playing a critical role in neuroinflammation and neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	AIM2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	37 kDa
Amino Acids	90 aa
Pathways	pyroptosis, Autophagy, Ferroptosis, Oxidative Stress, NF-kB signaling
GeneCards	AIM2
Human Protein Atlas	AIM2
Associated Diseases	Als, Atherosclerosis, Cancer, Dementia, Infection
Interactions	ACTB, Actin, ALZHEIMER, AMPK, AND, APOPTOSIS
KG Connections	403 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    A["Gene expression"] --> B["AIM2 PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AIM2 PROTEIN in their description or question text

No additional research found