Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS/STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CGAS/STING PATHWAY |
Knowledge base pages for this entity
graph TD
CGAS_STING_PATHWAY["CGAS/STING PATHWAY"]
CGAS_STING_PATHWAY -->|"activates"| Type_I_Interferon_Signaling["Type I Interferon Signaling"]
CGAS_STING_PATHWAY -->|"modulates"| oncogenesis["oncogenesis"]
CGAS_STING_PATHWAY -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
CGAS_STING_PATHWAY -->|"activates"| ANXA1["ANXA1"]
CGAS_STING_PATHWAY -->|"modulates"| Immune_Microenvironment["Immune Microenvironment"]
CGAS_STING_PATHWAY -->|"regulates"| IL_6["IL-6"]
CGAS_STING_PATHWAY -->|"regulates"| TNF__["TNF-alpha"]
CGAS_STING_PATHWAY -->|"activates"| microglia["microglia"]
ANXA1 -->|"inhibits"| CGAS_STING_PATHWAY
TDP_43["TDP-43"] -->|"activates"| CGAS_STING_PATHWAY
Loss_of_ANXA1["Loss of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
Loss_Of_ANXA1["Loss Of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
ANXA1_Deficiency_In_Macrophage["ANXA1 Deficiency In Macrophages"] -->|"activates"| CGAS_STING_PATHWAY
TDP43["TDP43"] -->|"activates"| CGAS_STING_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| Type I Interferon Signaling | activates | pathway | 0.95 |
| Senescence-Related Disorders | involved_in | disease | 0.90 |
| Cancer | involved_in | disease | 0.90 |
| Necroptosis | activates | process | 0.90 |
| oncogenesis | modulates | process | 0.88 |
| Amyotrophic Lateral Sclerosis | implicated_in | disease | 0.85 |
| Α-Synucleinopathy | associated_with | disease | 0.82 |
| ANXA1 | activates | gene | 0.80 |
| Immune Microenvironment | modulates | process | 0.80 |
| Amyotrophic Lateral Sclerosis | involved_in | disease | 0.80 |
| IL-6 | regulates | protein | 0.70 |
| TNF-α | regulates | protein | 0.70 |
| microglia | activates | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ANXA1 | inhibits | protein | 0.95 |
| ANXA1 | regulates | protein | 0.90 |
| TDP-43 | activates | protein | 0.90 |
| Loss of ANXA1 | activates | process | 0.90 |
| Loss of ANXA1 | activates | mechanism | 0.90 |
| Loss Of ANXA1 | activates | phenotype | 0.90 |
| ANXA1 Deficiency In Macrophages | activates | phenotype | 0.88 |
| Tardbp | activates | protein | 0.88 |
| TDP43 | activates | protein | 0.85 |
| ANXA1 | regulates | protein | 0.85 |
| Hydrogen sulfide | inhibits | compound | 0.85 |
| ANXA1 | inhibits | gene | 0.80 |
| mtDNA | activates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||