concept

CGAS/STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS/STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections
0Hypotheses
0Analyses
13Outgoing
13Incoming

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💡 Concept Info
NameCGAS/STING PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Novel Therapy Index

idea · 10647 words

neuroinflammation

mechanism · 5462 words

metal-ion-synuclein-mitochondria-axis-parkinsons

general · 4097 words

Neuroinflammation-Mitochondria Crosstalk Pathway

mechanism · 3966 words

DNA Damage Response Impairment Pathway

mechanism · 3871 words

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS/STING PATHWAY"]
    CGAS_STING_PATHWAY -->|"activates"| Type_I_Interferon_Signaling["Type I Interferon Signaling"]
    CGAS_STING_PATHWAY -->|"modulates"| oncogenesis["oncogenesis"]
    CGAS_STING_PATHWAY -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CGAS_STING_PATHWAY -->|"activates"| ANXA1["ANXA1"]
    CGAS_STING_PATHWAY -->|"modulates"| Immune_Microenvironment["Immune Microenvironment"]
    CGAS_STING_PATHWAY -->|"regulates"| IL_6["IL-6"]
    CGAS_STING_PATHWAY -->|"regulates"| TNF__["TNF-alpha"]
    CGAS_STING_PATHWAY -->|"activates"| microglia["microglia"]
    ANXA1 -->|"inhibits"| CGAS_STING_PATHWAY
    TDP_43["TDP-43"] -->|"activates"| CGAS_STING_PATHWAY
    Loss_of_ANXA1["Loss of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
    Loss_Of_ANXA1["Loss Of ANXA1"] -->|"activates"| CGAS_STING_PATHWAY
    ANXA1_Deficiency_In_Macrophage["ANXA1 Deficiency In Macrophages"] -->|"activates"| CGAS_STING_PATHWAY
    TDP43["TDP43"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (13)

TargetRelationTypeStr
Type I Interferon Signalingactivatespathway0.95
Senescence-Related Disordersinvolved_indisease0.90
Cancerinvolved_indisease0.90
Necroptosisactivatesprocess0.90
oncogenesismodulatesprocess0.88

Incoming (13)

SourceRelationTypeStr
ANXA1inhibitsprotein0.95
ANXA1regulatesprotein0.90
TDP-43activatesprotein0.90
Loss of ANXA1activatesprocess0.90
Loss of ANXA1activatesmechanism0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found