gene

MTDNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTDNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1151Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MTDNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 733 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MTDNA
Primary Expression	Spinal Cord
Pathways	Mitophagy, Nf-Κb, Oxidative Stress, Apoptosis, Autophagy
GeneCards	MTDNA
Human Protein Atlas	MTDNA
Associated Diseases	Aging, Als, Alzheimer, Autism, Autoimmune
Interactions	Actin, AGING, AIM2, AKT, ALS, ALZHEIMER
KG Connections	1111 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    MTDNA["MTDNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MTDNA["MTDNA"] -->|"activates"| Als["Als"]
    MTDNA["MTDNA"] -->|"activates"| Inflammation["Inflammation"]
    MTDNA["MTDNA"] -->|"activates"| Aging["Aging"]
    MTDNA["MTDNA"] -->|"activates"| Ms["Ms"]
    MTDNA["MTDNA"] -->|"associated"| Carcinoma["Carcinoma"]
    TDP43["TDP43"] -->|"causes"| MTDNA["MTDNA"]
    STING["STING"] -->|"activates"| MTDNA["MTDNA"]
    CGAS["CGAS"] -->|"activates"| MTDNA["MTDNA"]
    GPX4["GPX4"] -->|"associated"| MTDNA["MTDNA"]
    style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (708)

Target	Relation	Type	Str
MTDNA	encodes	protein	0.00
Mitophagy	activates	pathway	1.00
MITOCHONDRIA	activates	gene	1.00
DNA	activates	gene	1.00
DNA	associated_with	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
CGAS-STING	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
Als	activates	disease	1.00
Mitochondrial Function	activates	pathway	1.00
Inflammation	activates	disease	1.00
STING	activates	gene	1.00
Autophagy	activates	pathway	1.00
Oxidative Phosphorylation	involved_in	process	0.95
Oxidative Phosphorylation	associated_with	process	0.95
Neuroinflammation	activates	disease	0.95
Neurodegeneration	activates	disease	0.95
Inflammation	inhibits	disease	0.95
13 PROTEINS	encodes	protein	0.95
Cancer	therapeutic_target	disease	0.95
CGAS	activates	protein	0.94
Mitochondrial Disorders	associated_with	disease	0.90
mitochondrial respiration	regulates	process	0.90
Mitochondrial Disorders	biomarker_for	disease	0.90
mitochondrial proteome	associated_with	protein	0.90
DNA	inhibits	gene	0.90
NF-κB	activates	protein	0.88
IL-6	activates	protein	0.88
Aging	activates	disease	0.85
Als	inhibits	disease	0.85
Ischemia	inhibits	disease	0.85
Alzheimer	activates	disease	0.85
Neuroinflammation	promotes	process	0.85
Als	associated_with	disease	0.85
Cancer	activates	disease	0.85
Parkinson	activates	disease	0.85
cGAS-STING Pathway	activates	pathway	0.85
Senescence	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Neurodegeneration	associated_with	disease	0.85
Mitochondrial Proteome	contributes_to	protein	0.80
NLRP3	activates	protein	0.80
Mitochondrial Function	involved_in	process	0.80
Mitochondrial Function	regulates	process	0.80
Neuroinflammation	associated_with	process	0.80
Oxidative Stress	inhibits	pathway	0.80
Apoptosis	activates	pathway	0.80
GENES	activates	gene	0.80
GENES	associated_with	gene	0.80
AGING	activates	gene	0.80

Incoming (443)

Source	Relation	Type	Str
MTDNA	encodes	gene	0.00
ROS	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
MITOCHONDRIAL DNA	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
CGAS	activates	gene	1.00
PINK1	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIAL DNA	causes	gene	1.00
DNA	activates	gene	1.00
Mtros	downregulates	compound	0.90
TFAM	binds_to	protein	0.90
TFAM	regulates	protein	0.90
zalcitabine	causes	drug	0.90
mtROS	associated_with	process	0.90
oxidative stress	causes	process	0.90
APOPTOSIS	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
TFAM Knockdown	downregulates	process	0.85
Mitochondrial Fission	causes	process	0.85
POLG	involved_in	gene	0.85
POLG	regulates	protein	0.80
CGAS	binds	gene	0.80
IMPAIRED_MITOPHAGY	increases	process	0.80
MITOCHONDRIAL_DYSFUNCTION	increases	process	0.80
VDAC	mediates	protein	0.80
INFLAMMATION	inhibits	gene	0.80
PARKIN	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
NF-ΚB	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
NEUROINFLAMMATION	activates	gene	0.80
CYTOKINES	activates	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
GENES	associated_with	gene	0.80
ATM	modulates	protein	0.75
TDP43	causes	protein	0.72
mitochondrial oxidative stress	activates	process	0.70
MITOCHONDRIAL DNA	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
IRF3	activates	gene	0.70
CANCER	causes	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
SSBP1	regulates	protein	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Severely Depleted mtDNA and Impaired OXPHOS Defines Senescen	0.520	neurodegeneration	How can senescent microglia be molecular
cGAS Inhibitors for ALS Therapeutics: Targeting Upstream mtD	0.380	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

neuroinflammation | 2026-04-07 | 8 hypotheses Top: 0.821

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023	0
Inflammasome assembly in neurodegenerative diseases. [PMID:37633753]	Singh J, Habean ML, Panicker N	Trends in neurosciences	2023	0
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938]	Li S, Sun Y, Song M, Song Y, Fang Y, Zha	JCI insight	2021	0
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407]	Gordon R, Albornoz EA, Christie DC, Lang	Science translational medicine	2018	0

Debates (1)

Multi-agent debates referencing this entity

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning MTDNA in their description or question text

No additional research found