Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COGNITIVE PERFORMANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | COGNITIVE PERFORMANCE |
graph TD
COGNITIVE_PERFORMANCE[COGNITIVE PERFORMANCE]
Amyloid___Deposition[Amyloid-Β Deposition] -->|correlates_with| COGNITIVE_PERFORMANCE
Amyloid_beta[Amyloid-beta] -->|downregulates| COGNITIVE_PERFORMANCE
A0A0G2JRQ6[A0A0G2JRQ6] -->|correlates_with| COGNITIVE_PERFORMANCE
C1QC[C1QC] -->|correlates_with| COGNITIVE_PERFORMANCE
GP1BB[GP1BB] -->|correlates_with| COGNITIVE_PERFORMANCE
RSU1[RSU1] -->|correlates_with| COGNITIVE_PERFORMANCE
hippocampus[hippocampus] -->|mediates| COGNITIVE_PERFORMANCE
BDNF[BDNF] -->|upregulates| COGNITIVE_PERFORMANCE
dorsal_striatum[dorsal striatum] -->|mediates| COGNITIVE_PERFORMANCE
IRON_CHELATORS[IRON CHELATORS] -->|improves| COGNITIVE_PERFORMANCE| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| 41000667 | rescued | paper | 0.90 |
| 41532810 | was not associated with | paper | 0.90 |
| caloric restriction | associated_with | phenotype | 0.90 |
| Amyloid Burden | associated_with | biomarker | 0.90 |
| Cholinergic Integrity | associated_with | biomarker | 0.90 |
| Amyloid-Β Deposition | correlates_with | phenotype | 0.88 |
| Amyloid-beta | downregulates | compound | 0.87 |
| Senolytics | associated_with | drug | 0.85 |
| GP1BB | correlates_with | protein | 0.85 |
| RSU1 | correlates_with | protein | 0.85 |
| hippocampus | mediates | brain_region | 0.85 |
| A0A0G2JRQ6 | correlates_with | protein | 0.85 |
| C1QC | correlates_with | protein | 0.85 |
| BDNF | upregulates | protein | 0.80 |
| Senescent Cell Clearance | associated_with | mechanism | 0.80 |
| SENOLYTICS | improves | drug | 0.80 |
| dorsal striatum | mediates | brain_region | 0.80 |
| Sleep Pattern Deviation | associated_with | phenotype | 0.80 |
| IRON CHELATORS | improves | drug | 0.80 |
| frontal cortex | mediates | brain_region | 0.78 |
| retrosplenial cortex | mediates | brain_region | 0.76 |
| Sleep Disruption | associated_with | phenotype | 0.75 |
| CREB | mediates | protein | 0.75 |
| gamma oscillations | regulates | phenotype | 0.70 |
| BMAL1 | regulates | protein | 0.70 |
| microglial depletion | activates | process | 0.70 |
| NMN | therapeutic_target_for | metabolite | 0.70 |
| 29563219 | can improve | paper | 0.60 |
| 31701892 | associated with | paper | 0.60 |
| HCRT | modulates | protein | 0.60 |
| 38254693 | typically show a negative correlation with | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.725
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-28
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-02
Hypotheses and analyses mentioning COGNITIVE PERFORMANCE in their description or question text
No additional research found