protein

CREB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1880Connections

10Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

CREB is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 570 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CREB
Function	Creb Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Primary Expression	hippocampus, cortex, prefrontal cortex, striatum, Prefrontal Cortex
Molecular Weight	37 kDa
Amino Acids	341 aa
Pathways	Methamphetamine Toxicity
GeneCards	CREB
Human Protein Atlas	CREB
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Cardiomyopathy, CHROMATIN REMODELING
Known Drugs/Compounds	EPIGALLOCATECHIN GALLATE, GENISTEIN, ketamine, Ketogenic Diet, LIRAGLUTIDE, memantine
Interactions	ABETA, ACAT1, ACHE, ACOX1, Actin, AD
KG Connections	1879 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Validated Hypothesis: CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control

hypothesis · 1169 words

→

Pathway Diagram

flowchart TD
    CREB(["CREB"])
    BDNF(["BDNF"])
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    Als["Als"]
    Inflammation["Inflammation"]
    Oxidative_Stress["Oxidative Stress"]
    AKT(["AKT"])
    Depression["Depression"]
    Neurodegeneration["Neurodegeneration"]
    PKA(["PKA"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    AMPK(["AMPK"])
    APOPTOSIS(["APOPTOSIS"])
    Apoptosis["Apoptosis"]
    ERK(["ERK"])

    CREB -->|"activates"| BDNF
    CREB -->|"activates"| OXIDATIVE_STRESS
    CREB -->|"activates"| Als
    CREB -->|"activates"| Inflammation
    CREB -->|"activates"| Oxidative_Stress
    CREB -->|"activates"| AKT
    CREB -->|"activates"| Depression
    CREB -->|"activates"| Neurodegeneration
    CREB -->|"regulates"| BDNF
    PKA -->|"activates"| CREB
    CREB -->|"activates"| NEURODEGENERATION
    CREB -->|"activates"| AMPK
    CREB -->|"activates"| APOPTOSIS
    CREB -->|"activates"| Apoptosis
    CREB -->|"activates"| ERK

    style CREB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1241)

Target	Relation	Type	Str
CREB	encodes	protein	0.00
AKT	activates	gene	1.00
Inflammation	activates	disease	1.00
BDNF	activates	protein	1.00
Als	activates	disease	1.00
Oxidative Stress	activates	pathway	1.00
Neurodegeneration	activates	disease	0.95
Depression	activates	disease	0.95
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
BDNF	regulates	protein	0.90
BDNF-TrkB signaling	participates_in	pathway	0.90
BDNF	upregulates	protein	0.90
miR-132 expression	activates	process	0.90
CREB signaling	participates_in	pathway	0.90
APOPTOSIS	activates	gene	0.90
ERK	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
Apoptosis	activates	pathway	0.90
AMPK	activates	gene	0.90
DEPRESSION	activates	gene	0.90
Cognitive Impairment	involved_in	phenotype	0.85
Alzheimer	activates	disease	0.85
Neuroinflammation	activates	disease	0.85
Traumatic Brain Injury	activates	disease	0.85
neurotrophin signaling	participates_in	pathway	0.85
Alzheimer	therapeutic_target	disease	0.85
neurons	activates	cell_type	0.80
Methamphetamine Toxicity	involved_in	mechanism	0.80
cortex	expressed_in	brain_region	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
hippocampus	expressed_in	brain_region	0.80
VAMP8	regulates	gene	0.80
GENES	activates	gene	0.80
ROS	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
TNF	activates	gene	0.80
ALZHEIMER	therapeutic_target	gene	0.80
MICROGLIA	activates	gene	0.80
Mapk	activates	pathway	0.80
SIRT1	activates	gene	0.80
Als	protects_against	disease	0.75
Neurodegeneration	protects_against	disease	0.75
Obesity	activates	disease	0.75
Stroke	activates	disease	0.75
Aging	activates	disease	0.75
PKA	activates	gene	0.75
Alzheimer	inhibits	disease	0.75
Tumor	activates	disease	0.75

Incoming (639)

Source	Relation	Type	Str
CREB	encodes	gene	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
APOPTOSIS	associated_with	gene	1.00
Antidepressant Treatment	upregulates	process	0.90
Copper	suppresses	compound	0.90
ERK	phosphorylates	protein	0.90
BDNF	activates	gene	0.90
PKA	activates	protein	0.90
Neuronal Activity	activates	process	0.88
GSK-3β	upstream_of	protein	0.88
CRTC2	interacts_with	protein	0.85
Pcs	modulates	compound	0.85
TRKB	phosphorylates	protein	0.85
Ketogenic Diet	activates	drug	0.85
CAMK2	phosphorylates	gene	0.85
ABETA	inhibits	protein	0.80
EPIGALLOCATECHIN GALLATE	targets	compound	0.80
rapamycin	targets	drug	0.80
GENISTEIN	targets	compound	0.80
antidepressant treatments	upregulates	process	0.80
SIGMAR1	regulates	gene	0.80
APP	associated_with	gene	0.80
BDNF	treats	gene	0.80
MTOR	activates	gene	0.74
TAU	associated_with	protein	0.74
BDNF	interacts_with	gene	0.74
ACHE	expresses	gene	0.70
CCL2	regulates	gene	0.70
ADORA2A	causes	gene	0.70
ATG7	activates	gene	0.70
CGAS	interacts_with	gene	0.70
ADORA2A	activates	gene	0.70
BDNF	biomarker_for	gene	0.70
BDNF	regulates	gene	0.70
CDK5	inhibits	gene	0.70
CHOLINERGIC	inhibits	cell_type	0.70
ATG5	activates	gene	0.70
AMPK	protects_against	gene	0.70
CDK5	activates	gene	0.70
ATG5	interacts_with	gene	0.70
BDNF	expressed_in	gene	0.70
ERK	activates	protein	0.70
DLAT	regulates	gene	0.70
Tirzepatide	activates	drug	0.70
CBP	regulates	gene	0.70
ALS	stabilizes	disease	0.70
LIRAGLUTIDE	activates	drug	0.70
ATG	regulates	gene	0.70
KDM6A	interacts_with	gene	0.70

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CREB-Dependent Differential Complement Regulator Positioning	0.833	synaptic-biology	What determines the selectivity of compl
Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signa	0.646	synaptic-biology	What determines the selectivity of compl
ADCY8-PKA-CREB Spatial Memory Enhancement	0.455	memory-and-navigation	How does ADCY8 mechanistically regulate
CREB1-Induced lncRNA-9969 Selectively Sequesters miR-6361 Th	0.380	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through	0.380	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

CREB-Mediated Differential CD55/CD46 Expression Creates Acti	0.380	synaptic-biology	What determines the selectivity of compl
Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Sign	0.380	synaptic-biology	What determines the selectivity of compl
CREB-Mediated Differential CD55/CD46 Expression Creates Acti	0.380	synaptic-biology	What determines the selectivity of compl
Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Sign	0.380	synaptic-biology	What determines the selectivity of compl
Perivascular Cell Reprogramming via CREB Inhibition	0.000	-	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (6)

Scientific analyses that reference this entity

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 0 hypotheses

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

neurodegeneration | 2026-04-13 | 0 hypotheses

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

Can circadian interventions selectively target microglia without affecting other

neuropharmacology | 2026-04-10 | 7 hypotheses

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

The debate highlighted a critical cell-type specificity gap where no evidence ex

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Investigate shared DNA methylation age acceleration and histone modification pat

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

The study identifies ADCY8 as associated with migratory distance differences and

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning CREB in their description or question text

CREB

Understanding Entity Pages

Summary

Wiki Pages (14)

CREB Signaling in Neurodegeneration

CREB-independent Neuronal Survival Pathways

CREB Neurons

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

CREB5 — cAMP Responsive Element Binding Protein 5

Validated Hypothesis: CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control

Pathway Diagram

Outgoing (1241)

Incoming (639)

Targeting Hypotheses (10)

Mentioning Analyses (6)

Comparative epigenetic signatures: DNA methylation age acceleration and histone

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Can circadian interventions selectively target microglia without affecting other

What neural circuits encode and maintain multi-generational migratory route memo

How does ADCY8 mechanistically regulate long-term memory formation in migratory

Experiments (0)

Related Papers (0)

Debates (6)

The debate highlighted a critical cell-type specificity gap where no evidence ex

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

Investigate shared DNA methylation age acceleration and histone modification pat

PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet

The study identifies ADCY8 as associated with migratory distance differences and

The paper describes memory-based migration routes maintained across generations

Related Research

CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl

Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling

CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl

Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling

Perivascular Cell Reprogramming via CREB Inhibition

CREB

Understanding Entity Pages

Summary

Wiki Pages (14)

CREB Signaling in Neurodegeneration

CREB-independent Neuronal Survival Pathways

CREB Neurons

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

CREB5 — cAMP Responsive Element Binding Protein 5

Validated Hypothesis: CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control

CREB1 Protein

CREBBP Protein

CREB1 Gene

CREB Protein

CREBBP Gene

CREB3 Gene

CREB5 Protein — cAMP Responsive Element Binding Protein 5

CREB3L1 Gene

Pathway Diagram

Outgoing (1241)

Incoming (639)

Targeting Hypotheses (10)

Mentioning Analyses (6)

Comparative epigenetic signatures: DNA methylation age acceleration and histone

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Can circadian interventions selectively target microglia without affecting other

What neural circuits encode and maintain multi-generational migratory route memo

How does ADCY8 mechanistically regulate long-term memory formation in migratory

Experiments (0)

Related Papers (0)

Debates (6)

The debate highlighted a critical cell-type specificity gap where no evidence ex

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

Investigate shared DNA methylation age acceleration and histone modification pat

PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet

The study identifies ADCY8 as associated with migratory distance differences and

The paper describes memory-based migration routes maintained across generations

Related Research

CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl

Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling

CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Compl

Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling

Perivascular Cell Reprogramming via CREB Inhibition