concept

FRONTAL CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTAL CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FRONTAL CORTEX
Key Genes/Proteins	TAU, APP, LRP1, SNAP25, SIRT1
Related Diseases	DEMENTIA, AUTOPHAGY, HUNTINGTON, PARKINSON, CERAMIDE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FRONTAL_CORTEX["FRONTAL CORTEX"]
    FRONTAL_CORTEX -->|"interacts"| subgenual_cingulate_cortex["subgenual cingulate cortex"]
    FRONTAL_CORTEX ---|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    FRONTAL_CORTEX ---|"associated"| GLUTAMATE["GLUTAMATE"]
    FRONTAL_CORTEX ---|"associated"| SLC1A2["SLC1A2"]
    FRONTAL_CORTEX ---|"associated"| APOE["APOE"]
    FRONTAL_CORTEX ---|"associated"| AQP4["AQP4"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] ---|"associated"| FRONTAL_CORTEX
    NEURODEGENERATION["NEURODEGENERATION"] ---|"associated"| FRONTAL_CORTEX
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] ---|"associated"| FRONTAL_CORTEX

Outgoing (53)

Target	Relation	Type	Str
NEURONS	associated_with	cell_type	0.50
APP	associated_with	gene	0.50
HUNTINGTON	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
DEMENTIA	associated_with	disease	0.50
TAU	associated_with	protein	0.50
CERAMIDE	associated_with	phenotype	0.50
LRP1	associated_with	gene	0.50
SNAP25	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
MICROGLIA	associated_with	cell_type	0.50
ACSL4	associated_with	gene	0.50
VCP	associated_with	gene	0.50
AMYLOID	associated_with	protein	0.50
SCHIZOPHRENIA	associated_with	disease	0.45
GLUTAMATE	associated_with	phenotype	0.45
SLC1A2	associated_with	gene	0.45
APOE	associated_with	gene	0.45
AQP4	associated_with	gene	0.45
CHOLESTEROL	associated_with	phenotype	0.45
DEPRESSION	associated_with	disease	0.45
CYP46A1	associated_with	gene	0.45
ABCA1	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
INFLAMMATION	associated_with	phenotype	0.45
PSEN1	associated_with	gene	0.45
PSEN2	associated_with	gene	0.45
TDP-43	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
OPTN	associated_with	gene	0.45
ALS	associated_with	disease	0.45
TREM2	associated_with	gene	0.45
CX3CR1	associated_with	gene	0.45
HMGCR	associated_with	gene	0.45
LDLR	associated_with	gene	0.45
ISCHEMIA	associated_with	disease	0.45
BIN1	associated_with	gene	0.45
MAPT	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
C9orf72	associated_with	gene	0.45
CD33	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
CASP3	associated_with	gene	0.45
GRN	associated_with	gene	0.45
DAM	associated_with	cell_type	0.45
BDNF	associated_with	gene	0.45
NTRK2	associated_with	gene	0.45
BAX	associated_with	gene	0.45

Incoming (24)

Source	Relation	Type	Str
DEMENTIA	activates	disease	0.70
AUTOPHAGY	transports	phenotype	0.65
TAU	inhibits	protein	0.65
AUTOPHAGY	expressed_in	phenotype	0.55
PYRAMIDAL NEURONS	associated_with	cell_type	0.50
PURKINJE CELLS	associated_with	cell_type	0.50
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.50
HUNTINGTON'S DISEASE	associated_with	disease	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.50
AUTOPHAGY	associated_with	phenotype	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
DNA METHYLATION	associated_with	phenotype	0.45
CHOLESTEROL METABOLISM	associated_with	phenotype	0.45
HISTONE ACETYLATION	associated_with	phenotype	0.45
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
GLYMPHATIC CLEARANCE	associated_with	phenotype	0.45
PROTEIN AGGREGATION	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FRONTAL CORTEX

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Atypical Parkinsonism

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

PI-2620 Tau PET in PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

NTF4 Protein

Mitochondrial Dysfunction in Parkinson's Disease

omega-3-fatty-acids-neurodegeneration

Cerebellar Function

VEGF/Angiogenesis Pathway in Neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

psp-tauopathy

dimethyl-fumarate-nrf2-ad-nct06850597

cognitive-reserve-cbs-psp

TDP-43 Proteinopathy