Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dopaminergic neuron: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | causes | process | 0.88 |
| T Cell | interacts_with | cell_type | 0.85 |
| LAG3 | suppresses | protein | 0.85 |
| Dopamine | expressed_in | compound | 0.85 |
| LNK | causes | protein | 0.85 |
| FGF21 | stimulates_differentiation | gene | 0.80 |
| Astrocyte | interacts_with | cell_type | 0.80 |
| ASTROCYTE | protects_against | cell_type | 0.80 |
| p38 | expressed_in | protein | 0.70 |
| FYN | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A | 0.790 | neurodegeneration | epigenetic reprogramming aging neurons |
| LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi | 0.783 | neurodegeneration | - |
| GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 | 0.750 | neurodegeneration | - |
| Chronic ISR Activation Represses Axonal Protein Synthesis in | 0.650 | parkinsons | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 0 hypotheses
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.662
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.703
neurodegeneration | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.67 · 2026-04-28
closed · Rounds: 4 · Score: 0.67 · 2026-04-28
closed · Rounds: 6 · Score: 0.89 · 2026-04-27
closed · Rounds: 4 · Score: 0.84 · 2026-04-16
closed · Rounds: 4 · Score: 0.68 · 2026-04-16
Hypotheses and analyses mentioning dopaminergic neuron in their description or question text
No additional research found