protein

P38

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1739Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

P38 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 1019 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P38
Chromosome	MAPK14: 6p21.31, MAPK11: 22q13.13, MAPK12: 15q21.2, MAPK13: 6p21.31
Protein Type	Kinase
Function	Upstream stress signals: Pro-inflammatory cytokines (IL-1β, TNF-α), oxidative stress, UV radiation, heat shock, and ischemia trigger activation
Primary Expression	neurons, microglia, and astrocytes
Molecular Weight	~38-40 kDa per isoform
Pathways	Akt, Apoptosis, Autophagy, Differentiation, Glycolysis
GeneCards	P38
Human Protein Atlas	P38
Gene Symbols	MAPK14 (p38α), MAPK11 (p38β), MAPK12 (p38γ), MAPK13 (p38δ)
UniProt IDs	Q16539 (p38α), P53778 (p38β), P53779 (p38γ), O15264 (p38δ)
Brain Expression	p38α: ubiquitous in neurons, microglia, astrocytes; p38β: lower expression; p38γ/p38δ: restricted
ATF2	Phosphorylation
CHOP (DDIT3)	Phosphorylation
MAPKAPK2/3	Kinase
Associated Diseases	Als, Alzheimer, Cancer, Carcinoma, Cardiac, Cardiovascular
Known Drugs/Compounds	RAPAMYCIN, Paeoniflorin, N-ACETYLCYSTEINE
Interactions	PIK3C3, AKT1, DDIT3, IFNG, PI3K, OPTN
KG Connections	1726 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P38["P38"] -->|"phosphorylates"| FOXN3["FOXN3"]
    P38["P38"] -->|"regulates"| NF_KB["NF-KB"]
    P38["P38"] -->|"associated"| INFLAMMATION["INFLAMMATION"]
    P38["P38"] -->|"interacts"| Cancer["Cancer"]
    P38["P38"] -->|"interacts"| Fibrosis["Fibrosis"]
    P38["P38"] -->|"interacts"| Als["Als"]
    GABARAP["GABARAP"] -->|"interacts"| P38["P38"]
    HSPA1A["HSPA1A"] -->|"regulates"| P38["P38"]
    ATG5["ATG5"] -->|"activates"| P38["P38"]
    GABARAP_1["GABARAP"] -->|"activates"| P38["P38"]
    style P38 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1039)

Target	Relation	Type	Str
JUN	activates	gene	1.00
Tumor	activates	disease	1.00
Als	activates	disease	1.00
Mapk	activates	pathway	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
Mapk	therapeutic_target	pathway	1.00
Inflammation	inhibits	disease	1.00
Mapk	inhibits	pathway	1.00
Als	therapeutic_target	disease	1.00
Als	inhibits	disease	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
P38 Mapk	activates	pathway	1.00
Infection	activates	disease	1.00
AKT	activates	gene	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
CANCER	activates	gene	1.00
Inflammation	regulates	disease	0.95
FOXN3	phosphorylates	gene	0.95
Inflammation	therapeutic_target	disease	0.95
Tumor	inhibits	disease	0.95
Cancer	therapeutic_target	disease	0.95
NF-KB	regulates	gene	0.90
Nf-Κb	activates	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
TNF-Α	activates	gene	0.90
Oxidative Stress	inhibits	pathway	0.90
ATF2	activates	protein	0.85
Neuroinflammation	activates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Tumor	regulates	disease	0.85
Neurodegeneration	activates	disease	0.85
INFLAMMATION	associated_with	gene	0.85
Neurodegeneration	regulates	disease	0.85
Cancer	inhibits	disease	0.85
LC3	activates	gene	0.80
Glycolysis	activates	pathway	0.80
Oxidative Stress	activates	pathway	0.80
Apoptosis	inhibits	pathway	0.80
GENES	activates	gene	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Nf-Κb	therapeutic_target	pathway	0.80
TNF-Α	inhibits	gene	0.80
MITOCHONDRIA	activates	gene	0.80
Differentiation	activates	pathway	0.80
P38 Mapk	contributes_to	pathway	0.80
INFLAMMATION	therapeutic_target	gene	0.80
AUTOPHAGY	activates	gene	0.80

Incoming (700)

Source	Relation	Type	Str
JNK	activates	gene	1.00
ERK	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
ERK1	activates	gene	1.00
PI3K	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00
CYTOKINES	activates	gene	1.00
CYTOKINES	inhibits	gene	1.00
ERK	inhibits	gene	1.00
PRMTM1	regulates	gene	0.90
JNK	inhibits	gene	0.90
NF-ΚB	activates	gene	0.90
APOPTOSIS	inhibits	gene	0.90
ROS	activates	gene	0.90
Paeoniflorin	targets	compound	0.88
TNF	activates	gene	0.80
BECN1	activates	gene	0.80
ERK1	regulates	gene	0.80
PI3K	therapeutic_target	gene	0.80
TNF	inhibits	gene	0.80
IL-6	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
OXIDATIVE STRESS	therapeutic_target	gene	0.80
NF-ΚB	therapeutic_target	gene	0.80
NEUROTOXICITY	activates	gene	0.80
SLC7A11	activates	gene	0.70
TNF	expressed_in	gene	0.70
ERK1	associated_with	gene	0.70
TAU	activates	gene	0.70
STAT3	activates	gene	0.70
PI3K	regulates	gene	0.70
BAX	expressed_in	gene	0.70
PTEN	activates	gene	0.70
JNK	regulates	gene	0.70
SOD1	phosphorylates	gene	0.70
SOD1	causes	gene	0.70
C-JUN	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
IL-6	expressed_in	gene	0.70
APOPTOSIS	regulates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
ERK	regulates	gene	0.70
NEURODEGENERATION	implicated_in	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
IL-6	inhibits	gene	0.70
ROS	inhibits	gene	0.70
OXIDATIVE STRESS	inhibits	gene	0.70
P53	inhibits	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.615	neurodegeneration	What is the therapeutic window between i

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine meth [PMID:39817908]	Aikio M, Odeh HM, Wobst HJ, Lee BL, Chan	Cell Rep	2025
Identification of energy metabolism-related biomarkers for risk prediction of he [PMID:36304554]	Chen H, Jiang R, Huang W, Chen K, Zeng R	Front Cardiovasc Med	2022
Calcium-dependent methylation by PRMT1 promotes erythroid differentiation throug [PMID:31541584]	Liu MY, Hua WK, Chiou YY, Chen CJ, Yao C	FEBS Lett	2020

P38

Understanding Entity Pages

Summary

Wiki Pages (21)

p38 MAPK Protein

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

NRF2 Oxidative Stress Pathway

Astrocyte Reactivity Mechanism

Pathway Diagram

Outgoing (1039)

Incoming (700)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Synaptic pruning by microglia in early AD

Digital biomarkers and AI-driven early detection of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Related Papers (3)

P38

Understanding Entity Pages

Summary

Wiki Pages (21)

p38 MAPK Protein

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

NRF2 Oxidative Stress Pathway

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

Vitamin D Signaling Pathway in Neurodegeneration

KARS1

IGF-1 Signaling Pathway in Neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Neuroinflammation Across AD, PD, ALS, FTD, and HD

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

Synaptic Plasticity Deficits in Neurodegeneration

substance-p-nk1-signaling-neurodegeneration

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

tau-hyperphosphorylation

Advanced Glycation End Products in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

CBS/PSP Genetic Architecture

Pathway Diagram

Outgoing (1039)

Incoming (700)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Synaptic pruning by microglia in early AD

Digital biomarkers and AI-driven early detection of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Related Papers (3)