Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about eIF2α phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| translation stalling | causes | mechanism | 0.90 |
| Alzheimer's disease | associated_with | disease | 0.90 |
| Parkinson's disease | associated_with | disease | 0.90 |
| ALS | associated_with | disease | 0.90 |
| stress granule assembly | activates | phenotype | 0.90 |
| G3BP1 stress granule clearance | inhibits | process | 0.70 |
| Alzheimer disease | associated_with | disease | 0.70 |
| TDP-43 mislocalization | causes | phenotype | 0.70 |
| als | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| eIF2α Phosphorylation Imbalance Creates Integrated Stress Re | 0.896 | als | - |
| H6: Aberrant eIF2α Phosphorylation Creates Stalled Translati | 0.856 | neurodegeneration | How do pathological stress granules tran |
| H6-V1: Aberrant eIF2α Phosphorylation Drives Mitochondrial T | 0.751 | neurodegeneration | How do pathological stress granules tran |
| eIF2α Phosphorylation Imbalance Disrupts Mitochondrial Prote | 0.000 | als | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-06 | 8 hypotheses Top: 0.856
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PERK Inhibitor GSK2606414 + GADD34 Mimetic Sephin1 Rescues eIF2alpha S | in_vitro | ALS / FTD | 0.830 | 0.85 | iPSC-derived motor neurons fro | completed | $67,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Calcium release from damaged lysosomes triggers stress granule formation for cel [PMID:39962896] | Jayabalan AK, Ayeni A, Jia J | Autophagy | 2025 | 0 |
| Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzb [PMID:41453885] | Chen Y, Kunjamma RB, Lin K | Nat Commun | 2025 | 0 |
| Oligodendrocyte-selective deletion of the eIF2α kinase Perk/Eif2ak3 limits funct [PMID:38587137] | Saraswat Ohri S, Forston MD, Myers SA | Glia | 2024 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrate [PMID:32086012] | Horn M, Denzel SI, Srinivasan B | iScience | 2020 | 0 |
| Quercetin Regulates the Integrated Stress Response to Improve Memory. [PMID:31195662] | Nakagawa T, Ohta K | Int J Mol Sci | 2019 | 0 |
| The UPR and synaptic dysfunction in neurodegeneration. [PMID:27021956] | Freeman OJ, Mallucci GR | Brain Res | 2016 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.84 · 2026-04-22
closed · Rounds: 4 · Score: 0.86 · 2026-04-16
Hypotheses and analyses mentioning eIF2α phosphorylation in their description or question text
No additional research found