Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PKR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PKR (EIF2AK2) is a 98 kDa serine/threonine kinase that plays critical roles in the integrated stress response, translational control, and neuroinflammation, with key implications for Alzheimer's disease, Parkinson's disease, and ALS
| Gene Symbol | PKR |
| Aliases | EIF2AK2, Protein Kinase R |
| Function | In the context of neurodegenerative disorders, PKR has emerged as a key player in the pathogenesis of Alzheimer's disease, Parkinson's disease, and other conditions. |
| Subcellular Localization | neurodegenerative diseases |
| Molecular Weight | 98 kDa |
| Pathways | Integrated Stress Response |
| GeneCards | PKR |
| Human Protein Atlas | PKR |
| Associated Diseases | ALS, Alzheimer's Disease, Tau Hyperphosphorylation |
| Known Drugs/Compounds | Aβ(1-42), tunicamycin |
| Interactions | GSK-3Β, RNA, STING, TLR, TGF, G3BP1 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PKR["PKR"]
Integrated_Stress_Response["Integrated Stress Response"]
PKR -->|"activates"| Integrated_Stress_Response
CANCER["CANCER"]
CANCER -->|"regulates"| PKR
CLUSTERIN["CLUSTERIN"]
CLUSTERIN -->|"co_discussed"| PKR
style PKR fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Integrated Stress Response | activates | pathway | 0.95 |
| TAU | phosphorylates | protein | 0.95 |
| Tau Hyperphosphorylation | causes | phenotype | 0.90 |
| GSK-3Β | activates | gene | 0.90 |
| tau phosphorylation | mediates | process | 0.88 |
| MAPT | upregulates | gene | 0.85 |
| tau | modulates | protein | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| apoptosis | associated_with | process | 0.80 |
| Chronic Traumatic Encephalopathy | contributes_to | disease | 0.75 |
| STING | activates | gene | 0.70 |
| RNA | activates | gene | 0.60 |
| neuroinflammation | interacts_with | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| ALS | associated_with | disease | 0.60 |
| TLR | regulates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| TLR | activates | gene | 0.60 |
| TGF | activates | gene | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| RAN | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| STING | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Aβ(1-42) | activates | compound | 0.90 |
| tunicamycin | activates | drug | 0.90 |
| Brain Inflammation | upregulates | process | 0.85 |
| IFN | regulates | gene | 0.60 |
| CD8 | activates | gene | 0.60 |
| ATG | regulates | gene | 0.60 |
| EIF2AK2 | activates | gene | 0.60 |
| EIF2S1 | activates | gene | 0.60 |
| G3BP1 | activates | gene | 0.55 |
| GCN2 | activates | gene | 0.55 |
| PERK | activates | gene | 0.55 |
| CANCER | regulates | gene | 0.50 |
| CLUSTERIN | co_discussed | protein | 0.50 |
| PERK | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||