protein

FUS-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUS-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

FUS Protein

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🔬 Protein Info

Gene Symbol	FUS
Full Name	PROTEIN
Chromosome	16p11.2.
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	Blood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt ID	Search UniProt
GeneCards	FUS
Human Protein Atlas	FUS
Associated Diseases	AD, Aging, ALI, als
Known Drugs/Compounds	ADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides
Interactions	ACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX Hypotheses	ASO-Mediated Exon Skipping to Restore FUS-TAZ Chap FUS Phase Separation Dominance in FTD-TDP: Aberran Arginine Methylation Loss on FUS RGG Domains Drive (+6 more)
KG Connections	1564 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — FUS-PROTEIN Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

2LCW — X-ray / Cryo-EM

🔮 AI Predicted Structure

P35637 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    FUS["FUS"]
    FERROPTOSIS["FERROPTOSIS"]
    FUS -->|"associated_with"| FERROPTOSIS
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    FUS -->|"inhibits"| MITOCHONDRIAL_DNA
    Prefrontal_Cortex["Prefrontal Cortex"]
    FUS -->|"expressed_in"| Prefrontal_Cortex
    GBA["GBA"]
    FUS -->|"interacts_with"| GBA
    GAA["GAA"]
    FUS -->|"therapeutic_target"| GAA
    autophagy_pathway["autophagy pathway"]
    FUS -->|"participates_in"| autophagy_pathway
    Aging["Aging"]
    FUS -->|"causes"| Aging
    Ms["Ms"]
    FUS -->|"associated_with"| Ms
    SOX10["SOX10"]
    FUS -->|"activates"| SOX10
    GENETIC_MUTATIONS["GENETIC MUTATIONS"]
    FUS -->|"associated_with"| GENETIC_MUTATIONS
    FIG4["FIG4"]
    FUS -->|"associated_with"| FIG4
    AGING["AGING"]
    FUS -->|"therapeutic_target"| AGING
    style FUS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style FERROPTOSIS fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIAL_DNA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Prefrontal_Cortex fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GBA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GAA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style autophagy_pathway fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SOX10 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GENETIC_MUTATIONS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style FIG4 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style AGING fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FUS-PROTEIN in their description or question text

No additional research found