gene 3,160 words KG: EPG5 2026-03-24
kind:genesection:genesstate:published
Contents

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

🧬 Gene Info
Gene SymbolEPG5
Full NameEctopic P-Granules 5 Autophagy Tutor
AliasesPage for EPG5 Gene
Chromosome18q12.3
FunctionAutophagosome maturation: EPG5 promotes the maturation of autophagosomes by facilitating their fusion with lysosomes
Primary ExpressionCerebral cortex, Brain stem, Spinal cord, Testis, Heart
Molecular Weight282 kDa
Amino Acids2573 aa
Exons36
PathwaysAutophagy
UniProt IDQ9H7D3
NCBI Gene ID2058
Ensembl IDENSG00000151692
OMIM614921
GeneCardsEPG5
Human Protein AtlasEPG5
Associated DiseasesGlioblastoma, Tumor
InteractionsSQSTM1, LAMP2, SNARE, MAP1LC3, GLIOBLASTOMA, TGM2
KG Connections82 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian Clock-Autophagy Synchronization
Score: 0.55
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.50

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (5)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: associated_with
LAMP2 Gene
gene · KG edge: associated_with
GLI Gene Family
gene · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
FUS (Redirect)
redirect · KG edge: regulates

Knowledge Graph (12 edges)

EPG5 associated_with STX17
EPG5 associated_with SQSTM1
EPG5 associated_with SNAP29
EPG5 associated_with SDC1
EPG5 associated_with TGM2
EPG5 associated_with LC3
EPG5 associated_with GBM
EPG5 associated_with LAMP2
EPG5 associated_with P62
EPG5 associated_with VAMP8