Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RIP3 is a concept in neurodegeneration research. Key relationships include: interacts with, activates, causes. Associated with AD, ALI, ALS. Connected to 177 entities in the SciDEX knowledge graph.
| Name | RIP3 |
| Key Genes/Proteins | DAI, RIP1 |
| Related Diseases | Parkinson'S Disease, Dopaminergic Neurodegeneration, glaucoma, Alzheimer, ALS |
| Related Pathways | necroptosis, apoptosis pathway |
Knowledge base pages for this entity
graph TD
RIP3["RIP3"]
RIP3 -->|"binds"| DAI["DAI"]
RIP3 -->|"interacts"| Alzheimer["Alzheimer"]
RIP3 -->|"interacts"| ALS["ALS"]
RIP3 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
RIP3 -->|"interacts"| Dementia["Dementia"]
RIP3 -->|"interacts"| Cardiovascular["Cardiovascular"]
RIP3 -->|"interacts"| Parkinson["Parkinson"]
RIP3 -->|"interacts"| PINK1["PINK1"]
RIP3 -->|"interacts"| LGALS3["LGALS3"]
RIP3 -->|"interacts"| FIP200["FIP200"]
BCL2L11["BCL2L11"] -->|"interacts"| RIP3
DNA["DNA"] -->|"interacts"| RIP3
NIX["NIX"] -->|"interacts"| RIP3
HIF1["HIF1"] -->|"interacts"| RIP3
RB1["RB1"] -->|"interacts"| RIP3
NLRP3["NLRP3"] -->|"interacts"| RIP3
PARKINSON["PARKINSON"] -->|"interacts"| RIP3
FMR1["FMR1"] -->|"interacts"| RIP3
RB1CC1["RB1CC1"] -->|"interacts"| RIP3
PARL["PARL"] -->|"interacts"| RIP3| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson'S Disease | protects_against | disease | 0.95 |
| Necroptosis | mediates | process | 0.90 |
| Dopaminergic Neurodegeneration | suppresses | phenotype | 0.90 |
| Apoptosis | involved_in | process | 0.85 |
| Neuroinflammation | involved_in | process | 0.85 |
| Astrocytes | regulates | cell_type | 0.85 |
| Microglia | regulates | cell_type | 0.80 |
| glaucoma | associated_with | disease | 0.70 |
| DAI | binds | protein | 0.70 |
| necroptosis | participates_in | pathway | 0.70 |
| apoptosis pathway | participates_in | pathway | 0.70 |
| Alzheimer | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| Necroptosis | therapeutic_target | disease | 0.65 |
| Neurodegeneration | protects_against | disease | 0.65 |
| Parkinson | protects_against | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| ALS | biomarker_for | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| PINK1 | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| DEMENTIA | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| Mitophagy | interacts_with | pathway | 0.60 |
| Apoptosis | interacts_with | pathway | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| Cell Cycle | interacts_with | pathway | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| LC3B | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| HIF | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RIP1 | interacts_with | gene | 0.70 |
| TNF | activates | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| NIX | interacts_with | gene | 0.60 |
| HIF1 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| PARKINSON | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| PARL | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| ALS | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| MITOCHONDRIA | interacts_with | gene | 0.60 |
| PGAM5 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| RETREG1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| MITOPHAGY | interacts_with | gene | 0.60 |
| HIF | interacts_with | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| BIM | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||