gene

NPY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

315Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

NPY is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 58 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNPY
Chromosome7p15.1
FunctionThe NPY gene encodes a prepropeptide that undergoes proteolytic processing to yield the mature NPY peptide.
Primary Expressionhippocampus, Hypothalamus, Brainstem, Thalamus, Amygdala
Amino Acids36 aa
PathwaysEr Stress, Mtor, Lipid Metabolism, Autophagy, Akt
Ensembl IDENSG00000157240
GeneCardsNPY
Human Protein AtlasNPY
CategoryCortical Interneurons
SubtypeGABAergic interneuron
LocationCortical layers 1-2, also layer 5
Primary NeurotransmitterGABA
NeuropeptidesNPY, Somatostatin
Key MarkersNPY, Reelin, COUP-TFII
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Asthma
InteractionsMTOR, NPY1R, GAIN, CRH, NGF, BDNF
KG Connections315 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Cortical Neurogliaform Cells

cell · 1084 words

Neurons — Cell Type Hierarchy

cell · 5551 words

gabaergic-dysfunction

mechanism · 4621 words

Paraventricular Hypothalamic Nucleus (PVN) Neurons

cell · 4274 words

Claustrum Neurons

cell · 3613 words

Melanotrophs

cell · 3529 words

Pathway Diagram

graph TD
    NPY["<b>NPY</b>"]
    Aging{"Aging"}
    NPY -->|"regulates"| Aging
    Ms{"Ms"}
    NPY -->|"regulates"| Ms
    Obesity{"Obesity"}
    NPY -->|"regulates"| Obesity
    Als{"Als"}
    NPY -->|"regulates"| Als
    NPY -->|"associated with"| Als
    NPY -->|"contributes to"| Ms
    Inflammation{"Inflammation"}
    NPY -->|"activates"| Inflammation
    ALS{"ALS"}
    NPY -->|"regulates"| ALS
    FOOD_INTAKE["FOOD_INTAKE"]
    NPY -->|"activates"| FOOD_INTAKE
    NTS["NTS"]
    NPY -->|"regulates"| NTS
    POMC["POMC"]
    NPY -->|"regulates"| POMC
    MTOR["MTOR"]
    NPY -->|"activates"| MTOR
    ARC["ARC"]
    ARC -->|"produces"| NPY
    CRH["CRH"]
    CRH -->|"regulates"| NPY
    POMC -->|"regulates"| NPY
    NTS -->|"regulates"| NPY
    ARC -->|"regulates"| NPY
    JAK["JAK"]
    JAK -->|"associated with"| NPY
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"contributes to"| NPY
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| NPY
    NPY1R["NPY1R"]
    NPY1R -->|"activates"| NPY
    AND["AND"]
    AND -->|"regulates"| NPY
    style NPY fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (208)

TargetRelationTypeStr
P38Kactivatespathway0.95
Excitotoxicityprotects_againstmechanism0.95
Pi3K/Aktactivatespathway0.95
MAPK/ERKactivatespathway0.95
Neuroinflammationsuppressesprocess0.95

Incoming (107)

SourceRelationTypeStr
Ketamine-Alnupregulatesdrug0.90
BDNFupregulatesprotein0.90
Ketamineupregulatesdrug0.80
ARCproducesbrain_region0.72
CRHregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found