concept

GUT DYSBIOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUT DYSBIOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

1Hypotheses

5Analyses

33Outgoing

4Incoming

0Experiments

13Debates

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💡 Concept Info

Name	GUT DYSBIOSIS

Pathway Diagram

graph TD
    GUT_DYSBIOSIS["GUT DYSBIOSIS"]
    GUT_DYSBIOSIS -->|"causes"| Gut_Brain_Axis_Dysfunction["Gut-Brain Axis Dysfunction"]
    GUT_DYSBIOSIS -->|"causes"| Blood_Brain_Barrier_Permeabili["Blood-Brain Barrier Permeability"]
    GUT_DYSBIOSIS -->|"causes"| Neuroinflammation["Neuroinflammation"]
    GUT_DYSBIOSIS -->|"causes"| Gut_Brain_Axis["Gut-Brain Axis"]
    GUT_DYSBIOSIS -->|"promotes"| neuroinflammation["neuroinflammation"]
    GUT_DYSBIOSIS -->|"causes"| Parkinson_s_disease["Parkinson's disease"]
    Probiotic_Supplementation["Probiotic Supplementation"] -->|"treats"| GUT_DYSBIOSIS
    Rotenone["Rotenone"] -->|"causes"| GUT_DYSBIOSIS

Outgoing (33)

Target	Relation	Type	Str
SCFA deficiency	causes	Metabolic state	1.00
Gut-Brain Axis Dysfunction	causes	process	0.92
SCFA deficiency	causes	mechanism	0.90
Butyrate	associated_with	compound	0.90
Butyrate-producing commensal depletion	causes	phenotype	0.90
Blood-Brain Barrier Permeability	causes	process	0.90
Neuroinflammation	causes	process	0.90
Parkinson's Disease	associated_with	disease	0.85
Alzheimer's Disease	contributes_to	disease	0.85
Gut-Brain Axis	causes	pathway	0.85
Neurodegeneration	associated_with	process	0.85
Butyrate	downregulates	compound	0.80
Neuroinflammation	contributes_to	process	0.80
neuroinflammation	promotes	process	0.75
Parkinson's Disease	contributes_to	disease	0.75
SCFA-producing commensals	inhibits	process	0.70
glaucoma	associated_with	disease	0.70
Th17 homeostatic cells	inhibits	cell_type	0.70
Parkinson Disease	associated_with	disease	0.70
Parkinson's disease	causes	disease	0.70
Amyloid-beta Aggregation	associated_with	process	0.70
inflammation	causes	mechanism	0.70
constipation	causes	phenotype	0.70
peripheral IL-1β elevation	causes	biomarker	0.70
LPS translocation	causes	process	0.70
Butyrate	reduces	biomarker	0.70
Parkinson's disease	risk_factor_for	disease	0.70
vagal cholinergic pathway disruption	causes	mechanism	0.70
neuroinflammation	causes	mechanism	0.70
intestinal permeability	increases	mechanism	0.70
cirrhosis	associated_with	disease	0.70
Short-chain fatty acid production	reduces	pathway	0.70
alpha-synuclein aggregation	activates	mechanism	0.50

Incoming (4)

Source	Relation	Type	Str
Lactococcus Lactis Mg1363-Pmg36E-Glp-1	associated_with	drug	0.90
Mitochondrial Dysfunction	causes	disease	0.85
Probiotic Supplementation	treats	drug	0.80
Rotenone	causes	compound	0.80