Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLUTAMATERGIC SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GLUTAMATERGIC SIGNALING |
| Key Genes/Proteins | BDNF |
| Related Diseases | STROKE, ALS, ALZHEIMER'S DISEASE |
Knowledge base pages for this entity
graph TD
GLUTAMATERGIC_SIGNALING["GLUTAMATERGIC SIGNALING"]
GLUTAMATERGIC_SIGNALING -->|"contributes to"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
GLUTAMATERGIC_SIGNALING -->|"activates"| cortical_hyperexcitability["cortical hyperexcitability"]
GLUTAMATERGIC_SIGNALING -->|"activates"| motor_neuron_hyperexcitability["motor neuron hyperexcitability"]
GLUTAMATERGIC_SIGNALING -->|"regulates"| MOTOR_NEURONS["MOTOR NEURONS"]
GLUTAMATERGIC_SIGNALING -->|"regulates"| WHITE_MATTER["WHITE MATTER"]
GLUTAMATERGIC_SIGNALING -->|"regulates"| GRAY_MATTER["GRAY MATTER"]
GLUTAMATERGIC_SIGNALING -->|"regulates"| NEURON["NEURON"]
GLUTAMATERGIC_SIGNALING -->|"regulates"| STROKE["STROKE"]
BIN1["BIN1"] -->|"regulates"| GLUTAMATERGIC_SIGNALING
EXCITOTOXICITY["EXCITOTOXICITY"] -->|"regulates"| GLUTAMATERGIC_SIGNALING
CORTEX["CORTEX"] -->|"regulates"| GLUTAMATERGIC_SIGNALING
ALS["ALS"] -->|"regulates"| GLUTAMATERGIC_SIGNALING
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| GLUTAMATERGIC_SIGNALING
BDNF["BDNF"] -->|"expressed in"| GLUTAMATERGIC_SIGNALING| Target | Relation | Type | Str |
|---|---|---|---|
| MOTOR NEURONS | regulates | cell_type | 0.35 |
| WHITE MATTER | regulates | brain_region | 0.35 |
| GRAY MATTER | regulates | brain_region | 0.35 |
| NEURON | regulates | cell_type | 0.35 |
| STROKE | regulates | disease | 0.35 |
| ORGANOIDS | activates | cell_type | 0.35 |
| NEURODEGENERATION | expressed_in | process | 0.35 |
| NEUROINFLAMMATION | expressed_in | process | 0.35 |
| OXIDATIVE STRESS | expressed_in | process | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EXCITOTOXICITY | regulates | process | 0.35 |
| CORTEX | regulates | brain_region | 0.35 |
| ALS | regulates | disease | 0.35 |
| ALZHEIMER'S DISEASE | regulates | disease | 0.35 |
| BDNF | expressed_in | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||