Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STROKE is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 1440 entities in the SciDEX knowledge graph.
| Gene Symbol | STROKE |
| Aliases | Cerebrovascular accident, CVA, Brain attack |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Known Drugs/Compounds | VITAMIN D, CURCUMIN, NMN, NICOTINAMIDE, RAPAMYCIN, QUERCETIN |
| Interactions | GENES, ALZHEIMER, CANCER, CAV1, CLDN5, UBIQUITIN |
| KG Connections | 3419 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STROKE["STROKE"] -->|"associated"| TREM2["TREM2"]
STROKE["STROKE"] -->|"associated"| Heart_Failure["Heart Failure"]
STROKE["STROKE"] -->|"associated"| Diabetes["Diabetes"]
STROKE["STROKE"] -->|"associated"| Cancer["Cancer"]
STROKE["STROKE"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
STROKE["STROKE"] -->|"associated"| Stroke["Stroke"]
APP["APP"] -->|"associated"| STROKE["STROKE"]
GDNF["GDNF"] -->|"associated"| STROKE["STROKE"]
GFAP["GFAP"] -->|"associated"| STROKE["STROKE"]
IGF1["IGF1"] -->|"associated"| STROKE["STROKE"]
style STROKE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | associated_with | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Stroke | activates | disease | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| Stroke | contributes_to | disease | 1.00 |
| Stroke | regulates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Ischemia | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Stroke | expressed_in | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| Neuroinflammation | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Stroke | causes | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Ischemia | associated_with | disease | 1.00 |
| Stroke | inhibits | disease | 1.00 |
| Cardiovascular | inhibits | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Ischemia | inhibits | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Inflammation | contributes_to | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Neuroinflammation | inhibits | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| BRAIN INJURY | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| FERROPTOSIS | associated_with | gene | 1.00 |
| ASTROCYTES | associated_with | cell_type | 1.00 |
| MICROGLIA | associated_with | cell_type | 1.00 |
| TNF | associated_with | gene | 1.00 |
| NRF2 | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| BRAIN INJURY | therapeutic_target | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| PI3K | associated_with | gene | 0.98 |
| MTOR | associated_with | gene | 0.90 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.90 |
| AMYLOID | associated_with | protein | 0.90 |
| NF-KB | associated_with | protein | 0.90 |
| CYTOKINES | activates | gene | 0.90 |
| BRAIN INJURY | activates | gene | 0.90 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.90 |
| NEURODEGENERATION | therapeutic_target | gene | 0.90 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.90 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.90 |
| OXIDATIVE STRESS | activates | gene | 0.90 |
| INFLAMMATION | associated_with | gene | 0.90 |
| BDNF | activates | gene | 0.90 |
| APOPTOSIS | inhibits | gene | 0.82 |
| APOE | associated_with | gene | 0.82 |
| MICROGLIA | regulates | gene | 0.82 |
| MICROGLIA | activates | gene | 0.82 |
| NEUROINFLAMMATION | activates | gene | 0.82 |
| MICROGLIA | interacts_with | gene | 0.82 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||