Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INNATE IMMUNE RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | INNATE IMMUNE RESPONSE |
Knowledge base pages for this entity
graph TD
INNATE_IMMUNE_RESPONSE["INNATE IMMUNE RESPONSE"]
INNATE_IMMUNE_RESPONSE -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
CGAS_STING_pathway["CGAS-STING pathway"] -->|"activates"| INNATE_IMMUNE_RESPONSE
ALPK1_TIFA_Axis["ALPK1-TIFA Axis"] -->|"involved_in"| INNATE_IMMUNE_RESPONSE
cGAS_STING["cGAS/STING"] -->|"involved_in"| INNATE_IMMUNE_RESPONSE
STING["STING"] -->|"activates"| INNATE_IMMUNE_RESPONSE
NLRC5["NLRC5"] -->|"activates"| INNATE_IMMUNE_RESPONSE
cGAS_STING_TBK1["cGAS-STING-TBK1"] -->|"regulates"| INNATE_IMMUNE_RESPONSE
STING_Pathway["STING Pathway"] -->|"mediates"| INNATE_IMMUNE_RESPONSE| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | contributes_to | process | 0.80 |
| Neuroinflammation | involved_in | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CGAS-STING pathway | activates | pathway | 0.95 |
| ALPK1-TIFA Axis | involved_in | pathway | 0.95 |
| cGAS/STING | involved_in | pathway | 0.95 |
| STING | activates | protein | 0.95 |
| APOE | regulates | gene | 0.95 |
| STING | activates | protein | 0.93 |
| Autophagy Inhibition | associated_with | process | 0.90 |
| NLRC5 | activates | protein | 0.90 |
| cGAS-STING-TBK1 | regulates | pathway | 0.90 |
| STING Pathway | mediates | pathway | 0.90 |
| TBEV | modulates | disease | 0.90 |
| STING | mediates | protein | 0.90 |
| STING | mediates | protein | 0.90 |
| Sting Protein | activates | protein | 0.90 |
| MYD88 | involved_in | gene | 0.85 |
| mitochondrial DNA | associated_with | compound | 0.85 |
| IFNG signaling | regulates | pathway | 0.85 |
| NF-κB | regulates | pathway | 0.85 |
| Act001 | regulates | compound | 0.80 |
| TAX1BP1 | modulates | protein | 0.80 |
| APOE4 | enhances | gene | 0.80 |
| Fibroblasts | mediates | cell_type | 0.80 |
| IFNG | promotes | gene | 0.80 |
| TFAM | suppresses | protein | 0.80 |
| LC3 | regulates | protein | 0.75 |
| PRMT inhibitor | modulates | drug | 0.75 |
| cGAS | activates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.588
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||