protein

CGAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1947Connections

1Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

CGAS is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1017 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CGAS
Chromosome	6q15
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of cyclic dinucleotide synthesis
Mechanism of Action	Small molecule inhibitor of cyclic dinucleotide synthesis
Druggability	Medium (0.47)
Clinical Stage	Phase III
Molecular Weight	57 kDa
Amino Acids	522 aa
Exons	8
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Calcium Signaling
UniProt ID	Q8N884
NCBI Gene ID	115004
Ensembl ID	ENSG00000154122
GeneCards	CGAS
Human Protein Atlas	CGAS
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	cGAS Inhibitors, Aberrant DNA, RAPAMYCIN, Mitochondrial DNA, Ginkgetin, Mitochondrial Dna
Interactions	STING1, DNASE2, PARP1, IRF3, SQSTM1, RPS6KB1
SciDEX Target	View Target Profile (4 clinical trials)
KG Connections	1914 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: CGAS — PDB 4LEV Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CGAS["CGAS"] -->|"activates"| STING["STING"]
    CGAS["CGAS"] -->|"activates"| NFKB["NFKB"]
    CGAS["CGAS"] -->|"activates"| IFN["IFN"]
    CGAS["CGAS"] -->|"mediates"| NEURODEGENERATION["NEURODEGENERATION"]
    CGAS["CGAS"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CGAS["CGAS"] -->|"interacts"| STING1["STING1"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL_DNA"] -->|"activates"| CGAS["CGAS"]
    MTDNA["MTDNA"] -->|"activates"| CGAS["CGAS"]
    TDP43["TDP43"] -->|"activates"| CGAS["CGAS"]
    STING1_1["STING1"] -->|"interacts"| CGAS["CGAS"]
    style CGAS fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1283)

Target	Relation	Type	Str
STING	activates	protein	1.00
STING	inhibits	gene	1.00
STING	therapeutic_target	gene	1.00
IFN	activates	protein	1.00
Tumor	activates	disease	1.00
Innate Immunity	activates	pathway	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Immune Response	activates	pathway	1.00
Inflammation	activates	disease	1.00
Autophagy	activates	pathway	1.00
Autoimmune	activates	disease	1.00
DNA	activates	gene	1.00
MTDNA	activates	gene	1.00
Als	inhibits	disease	1.00
Innate Immunity	regulates	pathway	1.00
Senescence	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Als	regulates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	inhibits	disease	1.00
CGAS-STING	inhibits	gene	1.00
CGAS-STING	activates	gene	1.00
CGAS-STING	implicated_in	gene	1.00
Infection	activates	disease	1.00
STING	regulates	gene	1.00
Autophagy	regulates	pathway	1.00
GENES	activates	gene	1.00
CGAS-STING	associated_with	gene	1.00
CGAS-STING	therapeutic_target	gene	1.00
Oxidative Stress	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Immune Response	causes	pathway	1.00
cGAMP	produces	protein	0.95
Type I Interferon Expression	activates	process	0.95
Cytosolic DNA	associated_with	process	0.95
DNA Repair	inhibits	process	0.95
Tumorigenesis	associated_with	process	0.95
Intracellular DNA Sensing	mediates	process	0.95
Cytosolic DNA	binds	biomarker	0.95
Innate Immune System	involved_in	process	0.95
Intracellular Dna Sensing	involved_in	process	0.95
Aberrant DNA	binds	compound	0.95
2'3'-cGAMP	produces	compound	0.95
Lysosome Biogenesis	upregulates	process	0.95
Aging	activates	disease	0.95
Als	associated_with	disease	0.95
Carcinoma	activates	disease	0.95
Inflammation	regulates	disease	0.95
Infection	regulates	disease	0.95

Incoming (664)

Source	Relation	Type	Str
TOLLIP	inhibits	protein	1.00
STING	activates	gene	1.00
TBK1	activates	gene	1.00
IRF3	activates	gene	1.00
DNA	activates	protein	1.00
DSDNA	activates	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
CYTOKINES	activates	gene	1.00
NLRP3	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
CANCER	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
cytosolic DNA	activates	protein	0.95
Mitochondrial DNA Release	activates	process	0.95
UL21	promotes_degradation_of	protein	0.95
MTDNA	activates	protein	0.94
UBE3C	catalyzes_ubiquitination_of	protein	0.93
UL21	inhibits	protein	0.90
Mitochondrial DNA	activates	compound	0.90
UBE3C	modifies	protein	0.90
h-1a34778f	targets_gene	hypothesis	0.90
h-bbe4540f	targets_gene	hypothesis	0.90
APOPTOSIS	activates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
FERROPTOSIS	activates	gene	0.90
NF-ΚB	regulates	gene	0.90
PYROPTOSIS	activates	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
self-DNA	activates	protein	0.85
FGF21	inhibits	protein	0.85
APOE	upregulates	gene	0.85
Mitochondrial Dna	activates	compound	0.85
Tetrahydroxy Stilbene Glucoside	downregulates	compound	0.85
nuclear localization	modulates	phenotype	0.85
PQBP1	activates	gene	0.80
h-1a34778f	targets	hypothesis	0.80
Mitochondrial Dna	binds	compound	0.80
h-bbe4540f	targets	hypothesis	0.80
LC3	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
INFLAMMATION	associated_with	gene	0.80
NEUROINFLAMMATION	regulates	gene	0.80
CYTOKINES	regulates	gene	0.80
NF-ΚB	activates	gene	0.80
PYROPTOSIS	inhibits	gene	0.80
MITOPHAGY	activates	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Senescence Circuit Disruption	0.486	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251]	Tomaskovic I, Prieto-Garcia C, Boskovic	Science	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749]	Zhang Q, Abudukadier A, Chen H, Xiong L,	Microbiol Spectr	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026
Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pa [PMID:41866990]	Barasa L, DeOrsey L, O'Reilly MD, Choudh	J Med Chem	2026
Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318]	Yang LM, Lu Y, Levine MS, Wang X, Shi YQ	J Am Chem Soc	2026
African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559]	Li X, Ren B, Zhang D, Dan M, Liu D et al	Autophagy	2026
Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625]	Song R, Ma Y, Wan J, Hao S, Chen B et al	Proc Natl Acad Sci U S A	2026

CGAS

Understanding Entity Pages

Summary

Wiki Pages (21)

CGAS Gene

Novel Therapy Index

Alzheimer's Disease Mechanism Index

neuroinflammation

Mitophagy Pathway in Neurodegeneration

metal-ion-synuclein-mitochondria-axis-parkinsons

Pathway Diagram

Outgoing (1283)

Incoming (664)

Targeting Hypotheses (1)

Mentioning Analyses (5)

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senolytic therapy for age-related neurodegeneration

Related Papers (14)

CGAS

Understanding Entity Pages

Summary

Wiki Pages (21)

CGAS Gene

Novel Therapy Index

Alzheimer's Disease Mechanism Index

neuroinflammation

Mitophagy Pathway in Neurodegeneration

metal-ion-synuclein-mitochondria-axis-parkinsons

Neuroinflammation-Mitochondria Crosstalk Pathway

mitophagy-defect

DNA Damage Response Impairment Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Vestibular Function Testing in Corticobasal Syndrome

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

TGF-β Signaling in Parkinson's Disease

Lipid Metabolism Dysregulation in Neurodegeneration

PBKR03

Portable Driving Simulator for PD Assessment (NCT03969927)

Epigenetic Mechanisms in Alzheimer's Disease

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration

Pathway Diagram

Outgoing (1283)

Incoming (664)

Targeting Hypotheses (1)

Mentioning Analyses (5)

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Senolytic therapy for age-related neurodegeneration

Related Papers (14)