Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRON OVERLOAD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IRON OVERLOAD |
Knowledge base pages for this entity
graph TD
IRON_OVERLOAD["IRON OVERLOAD"]
IRON_OVERLOAD -->|"activates"| ferroptosis["ferroptosis"]
IRON_OVERLOAD -->|"risk_factor_for"| Osteoarthritis["Osteoarthritis"]
IRON_OVERLOAD -->|"causes"| Hepatic_Fibrosis["Hepatic Fibrosis"]
IRON_OVERLOAD -->|"causes"| Neurotoxicity["Neurotoxicity"]
IRON_OVERLOAD -->|"causes"| Microglial_Transcriptional_Sta["Microglial Transcriptional State"]
IRON_OVERLOAD -.biomarker for.-> Bovine_Mastitis["Bovine Mastitis"]
IRON_OVERLOAD -->|"contributes to"| Non_Alcoholic_Fatty_Liver_Dise["Non-Alcoholic Fatty Liver Disease"]
IRON_OVERLOAD -->|"contributes to"| Sarcopenia["Sarcopenia"]
HAMP_Downregulation["HAMP Downregulation"] -->|"causes"| IRON_OVERLOAD
SLC40A1["SLC40A1"] -->|"causes"| IRON_OVERLOAD| Target | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | drives | process | 0.95 |
| ferroptosis | activates | phenotype | 0.90 |
| Hepatic Fibrosis | causes | disease | 0.90 |
| Microglia | associated_with | cell_type | 0.90 |
| Osteoarthritis | risk_factor_for | disease | 0.90 |
| Ferroptosis | causes | process | 0.90 |
| Neurotoxicity | causes | mechanism | 0.88 |
| Alzheimer's Disease | associated_with | disease | 0.88 |
| Microglial Transcriptional State | causes | phenotype | 0.85 |
| Bovine Mastitis | biomarker_for | disease | 0.85 |
| Non-Alcoholic Fatty Liver Disease | contributes_to | disease | 0.85 |
| Sarcopenia | contributes_to | disease | 0.85 |
| Neurodegeneration | associated_with | disease | 0.85 |
| Parkinson's disease | risk_factor_for | disease | 0.85 |
| Lysosomal functions | modulates | process | 0.80 |
| Neurodegeneration | causes | process | 0.80 |
| APOPTOSIS | causes | process | 0.80 |
| Neurodegeneration | contributes_to | process | 0.75 |
| ALZHEIMER'S DISEASE | contributes_to | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | associated_with | process | 0.95 |
| HAMP Downregulation | causes | process | 0.85 |
| SLC40A1 | causes | gene | 0.80 |
| apo-Tf | treats | protein | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||