gene

SLC40A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC40A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

0Experiments

Summary

Comprehensive guide to SLC40A1 (ferroportin) - iron metabolism, neurodegenerative diseases (NBIA, AD, PD), hepcidin regulation, and therapeutic targeting

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🧬 Gene Info

Gene Symbol	SLC40A1
Aliases	ferroportin
Function	SLC40A1 encodes ferroportin, the only known iron exporter in mammals.
Primary Expression	cells that export iron, including macrophages, hepatocytes, and enterocytes
Pathways	Inflammasome, Nf-Κb
Ensembl ID	ENSG00000138448
GeneCards	SLC40A1
Human Protein Atlas	SLC40A1
Iron export	Ferroportin exports iron from cells into the plasma
Systemic iron regulation	Controls iron entry into circulation from gut, liver, and spleen
Hepcidin receptor	Ferroportin is the target of hepcidin, the iron regulatory hormone
Cellular iron homeostasis	Prevents iron accumulation in macrophages and other cells
Iron overload	Mutations lead to iron accumulation in the brain, particularly in the globus pallidus
Motor symptoms	Patients present with progressive dystonia, parkinsonism, and gait disturbance
Cognitive decline	Some patients develop cognitive impairment
Associated Diseases	ALS, Cancer, iron overload
Interactions	IL6, C1QA, STAT1, STAT3, STAT4, TLR4
KG Connections	87 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC40A1["<b>SLC40A1</b>"]
    iron_overload["iron overload"]
    SLC40A1 -->|"causes"| iron_overload
    neurodegeneration["neurodegeneration"]
    SLC40A1 -->|"implicated in"| neurodegeneration
    hepcidin["hepcidin"]
    hepcidin -->|"regulates"| SLC40A1
    Nrf2["Nrf2"]
    Nrf2 -->|"upregulates"| SLC40A1
    miR_194_5p["miR-194-5p"]
    miR_194_5p -->|"inhibits"| SLC40A1
    copper["copper"]
    copper -->|"regulates"| SLC40A1
    style SLC40A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
iron overload	causes	phenotype	0.80
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ferroptosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
C1QA	therapeutic_target	gene	0.60
ASC	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
JAK1	expressed_in	gene	0.60
PCBP1	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
STAT4	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
NQO1	expressed_in	gene	0.60
JAK2	expressed_in	gene	0.60
STAT1	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
IL6	activates	gene	0.60
KEAP1	expressed_in	gene	0.60
C1QA	associated_with	gene	0.60
CD8	therapeutic_target	gene	0.60
STAT1	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
STAT4	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60
SLC7A11	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
RNA	therapeutic_target	gene	0.60
Macrophage	therapeutic_target	cell_type	0.60
ROS	activates	gene	0.60
GSH	activates	gene	0.60
HO-1	expressed_in	gene	0.60
FERROPTOSIS	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
macrophages	expressed_in	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
JAK-STAT signaling	participates_in	pathway	0.60
TFR1	co_mentioned	gene	0.55
Macrophage	expressed_in	cell_type	0.55
C1QA	interacts_with	gene	0.50
MACROPHAGES	interacts_with	concept	0.50

Incoming (36)

Source	Relation	Type	Str
hepcidin	regulates	protein	0.90
Nrf2	upregulates	transcription_factor	0.80
miR-194-5p	inhibits	gene	0.80
copper	regulates	chemical	0.80
CD8	therapeutic_target	gene	0.60
TLR4	expressed_in	gene	0.60
TXNIP	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
C1QA	therapeutic_target	gene	0.60
C1QA	interacts_with	gene	0.60
CD8	interacts_with	gene	0.60
C1QA	binds_to	gene	0.60
ASC	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
JAK1	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
PCBP1	inhibits	gene	0.60
ACSL4	biomarker_for	gene	0.60
CD163	biomarker_for	gene	0.60
CD206	biomarker_for	gene	0.60
CD36	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
HO1	biomarker_for	gene	0.60
IL6	biomarker_for	gene	0.60
LRP1	biomarker_for	gene	0.60
GFAP	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
HO1	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
COX2	inhibits	gene	0.60
GSH	biomarker_for	gene	0.60
DMT1	expressed_in	gene	0.55
C1QA	co_expressed_with	gene	0.50
CD8	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC40A1

Understanding Entity Pages

Summary

Wiki Pages (21)

SLC40A1 Gene

Ferroptosis in Alzheimer's Disease

Ferroptosis in Neurodegeneration

Iron Homeostasis Dysregulation in Neurodegeneration

Advanced Metal Chelation Therapy in CBS/PSP

SPG35 Gene

Ferroptosis Pathway in Alzheimer's Disease

Ferroptosis Pathway in Neurodegeneration

Iron Accumulation in 4R-Tauopathies: Cross-Disease Comparison

metal-dyshomeostasis

Metal Ion Dyshomeostasis in Corticobasal Syndrome

Metal Homeostasis Dysregulation in 4R-Tauopathies

Ferroptosis in Neurodegeneration

Metal Homeostasis Dysregulation in Neurodegeneration

Microglia in Frontotemporal Dementia Progression

Iron Dyshomeostasis in MSA Pathogenesis Experiment

SLC11A1

Transferrin Protein

Ferritin Light Chain (FTL)

Iron Chelation Therapy for Neurodegeneration