BLOOD-BRAIN BARRIER DYSFUNCTION

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

BLOOD-BRAIN BARRIER DYSFUNCTION is a concept in neurodegeneration research. Key relationships include: activates, contributes to, associated with. Associated with ALS, Aging, Als. Connected to 110 entities in the SciDEX knowledge graph.

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graph TD
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO["BLOOD-BRAIN BARRIER DYSFUNCTION"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"activates"| sepsis_associated_encephalopat["sepsis-associated encephalopathy"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Diabetes["Diabetes"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Aging["Aging"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"regulates"| Stroke["Stroke"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Als["Als"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Ischemia["Ischemia"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"inhibits"| Ms["Ms"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"contributes to"| Alzheimer["Alzheimer"]
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO -->|"contributes to"| ALS["ALS"]
    pericyte_senescence["pericyte senescence"] -->|"causes"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    pro_inflammatory_cytokines["pro-inflammatory cytokines"] -->|"activates"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    Amyloid__["Amyloid beta"] -->|"causes"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    SMAD2["SMAD2"] -->|"inhibits"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    AMYLOID["AMYLOID"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    ALZHEIMER["ALZHEIMER"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO
    AND["AND"] -->|"contributes to"| BLOOD_BRAIN_BARRIER_DYSFUNCTIO