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Tetramethylthiuram disulfide induces stress granules and DNA damage through oxidative stress in human lung epithelial cells.
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ID: paper-41822241
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Tetramethylthiuram disulfide induces stress granules and DNA damage through oxidative stress in human lung epithelial cells.
["Lin M", "Lee S", "Gwak J", "Cha J", "Hong S", "Kim E", "Kim K"]
Abstract
Tetramethylthiuram disulfide (TMTD), widely used in rubber manufacturing and agriculture, presents occupational inhalation hazards, yet its effects on human lung epithelial cells remain poorly characterized. Here, we investigated TMTD-induced cellular stress responses in A549 lung epithelial cells, focusing on stress granule formation, oxidative stress, and DNA damage. TMTD induced concentration-dependent cytotoxicity, with brief exposure producing effects comparable to continuous exposure, indi...
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