| Gene Symbol | SREBF2 |
| Full Name | Sterol Regulatory Element Binding Transcription Factor 2 |
| Chromosome | 22 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | SREBF2 plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms: |
| Mechanism of Action | Small molecule modulators of transcriptional activity or protein-protein interactions |
| Druggability | Undruggable (0.20) |
| Clinical Stage | Phase II |
| Pathways | Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Mitophagy |
| UniProt ID | A0AA34QVX2 |
| Ensembl ID | ENSG00000198911 |
| GeneCards | SREBF2 |
| Human Protein Atlas | SREBF2 |
| Associated Diseases | ALS, Alzheimer, neurodegeneration |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | ABCA1, LDLR, NFE2L2, C1Q, HTRA2, MTOR |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 557 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |