| Gene Symbol | A2M |
| Aliases | A2MPROTEIN |
| Chromosome | 12p13.31 (human) |
| Protein Family | α2-macroglobulin family |
| Function | The protein possesses a unique "trap" mechanism |
| Subcellular Localization | </strong></td><td>Secreted (plasma)</td></tr> |
| Molecular Weight | ~720 kDa (tetramer) |
| Amino Acids | 1450 amino acids |
| UniProt ID | P01023 |
| NCBI Gene ID | 2 |
| GeneCards | A2M |
| Human Protein Atlas | A2M |
| Homotetramer | Four identical subunits (~163 kDa each) arranged in a cloverleaf shape |
| Total molecular weight | ~720 kDa |
| Thioester bonds | Internal cysteine-glutamine thioesters for covalent protein binding |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer's disease, AMI, Depression |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE, APOPTOSIS |
| KG Connections | 110 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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