| Gene Symbol | ARC |
| Full Name | Activity-Regulated Cytoskeleton-Associated Protein |
| Chromosome | 8q24.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cortex and hippocampus with synaptic localization |
| Subcellular Localization | dendritic compartments for local translation near activated synapses |
| Pathways | Akt, Complement, Endocytosis, Exocytosis, Long-Term Potentiation |
| UniProt ID | Q7Z594 |
| NCBI Gene ID | 23237 |
| Ensembl ID | ENSG00000132740 |
| OMIM | 602473 |
| GeneCards | ARC |
| Human Protein Atlas | ARC |
| AMPA Receptor Endocytosis | Arc directly interacts with the endocytic machinery (dynamin, clathrin) to promote AMPA receptor internalization during LTD |
| Actin Cytoskeleton | Arc binds to actin filaments and regulates spine morphology through interactions with cortactin and cofilin |
| Associated Diseases | Als, Alzheimer, Glaucoma, Macular Degeneration, Retinopathy |
| Interactions | Actin, AGING, AIF1, Akt, AKT, ALZHEIMER |
| KG Connections | 245 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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