concept

ASRGL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASRGL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

27Outgoing

9Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ASRGL1
Key Genes/Proteins	TDP-43, HML-2
Related Diseases	Amyotrophic Lateral Sclerosis, Neuronal Viability, Als
Related Pathways	Tdp-43 Aggregation

Wiki Pages (1)

Knowledge base pages for this entity

TARDBP — TAR DNA Binding Protein 43

gene · 1363 words

→

Pathway Diagram

graph TD
    ASRGL1["ASRGL1"]
    ASRGL1 -->|"regulates"| TDP_43["TDP-43"]
    ASRGL1 -->|"modulates"| Isoaspartates["Isoaspartates"]
    ASRGL1 -.protects against.-> Neuronal_Viability["Neuronal Viability"]
    ASRGL1 -->|"causes"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ASRGL1 -->|"expressed in"| Als["Als"]
    ASRGL1 -->|"phosphorylates"| Neuron["Neuron"]
    ASRGL1 -->|"expressed in"| RNA["RNA"]
    HML_2["HML-2"] -->|"inhibits"| ASRGL1
    ALS["ALS"] -->|"expressed in"| ASRGL1
    TDP_43 -->|"causes"| ASRGL1
    RNA -->|"expressed in"| ASRGL1
    DNA["DNA"] -->|"causes"| ASRGL1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"causes"| ASRGL1

Outgoing (27)

Target	Relation	Type	Str
TDP-43	regulates	protein	0.95
TDP-43	substrate_of	protein	0.90
Isoaspartate	degrades	compound	0.90
Tdp-43 Aggregation	inhibits	mechanism	0.90
Isoaspartates	modulates	compound	0.85
TDP-43	degrades	protein	0.85
Amyotrophic Lateral Sclerosis	protects_against	disease	0.85
Neuronal Viability	promotes	phenotype	0.85
Neuronal Viability	protects_against	phenotype	0.80
TDP-43	interacts_with	protein	0.80
TDP-43	expressed_in	protein	0.75
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	expressed_in	disease	0.65
Neuron	phosphorylates	cell_type	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
HML-2	associated_with	gene	0.60
ALS	expressed_in	gene	0.60
Tdp-43	causes	pathway	0.60
Neuron	stabilizes	cell_type	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
TDP-43	causes	gene	0.60
DNA	causes	gene	0.60
Rb	contributes_to	protein	0.60
neurons	expressed_in	cell_type	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
HML-2	inhibits	gene	0.85
ALS	expressed_in	gene	0.60
TDP-43	causes	gene	0.60
RNA	expressed_in	gene	0.60
HML-2	associated_with	gene	0.60
DNA	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
ALS	implicated_in	gene	0.60
ALS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity