biomarker 877 words KG: S100BPROTEIN 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

S100B Protein - Astrocyte Biomarker

🔬 Protein Info
Gene SymbolS100B
Full NameS100 Calcium Binding Protein B
AliasesS100BPROTEIN
Chromosome21q22.3
Protein FamilyS100 EF-hand calcium binding proteins
Functionis a gene encoding a calcium-binding protein of the S100 family, playing crucial roles in neuronal function, astrocyte biology, and neuroinflammation.
Molecular Weight10.5 kDa
Amino Acids92 aa
PathwaysPI3K
UniProt ID[P16401](https://www.uniprot.org/uniprot/P16401)
Ensembl IDENSG00000122574
OMIM176990
GeneCardsS100B
Human Protein AtlasS100B
AstrocytesMost abundant source in the brain
Associated DiseasesAls, Cardiovascular, Glioma, Inflammation, Ms, Neurodegeneration
InteractionsC1Q, TGM2, GPNMB, HMGB1, APP, GFAP
KG Connections366 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Astrocyte-Mediated Microglial Memory Erasure
Score: 0.46
Heterogeneous astrocyte activation states differentially imp
Score: 0.52
Adenosine-Astrocyte Metabolic Reset
Score: 0.56
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (4)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in