| Gene Symbol | CDK9 |
| Aliases | Cyclin-Dependent Kinase 9 |
| Protein Type | Serine/Threonine Kinase |
| Function | The CDK9 gene encodes Cyclin-Dependent Kinase 9, a 372-amino acid serine/threonine kinase |
| Primary Expression | neurons throughout the cortex, hippocampus, and basal ganglia |
| Subcellular Localization | s. CDK9 activity is regulated by cellular stress, growth factors, and signaling pathways |
| Molecular Weight | 43 kDa |
| Amino Acids | 372 aa |
| Ensembl ID | ENSG00000136807 |
| GeneCards | CDK9 |
| Human Protein Atlas | CDK9 |
| Transcriptional Elongation | Catalytic subunit of P-TEFb; phosphorylates RNA Pol II CTD Ser2, NELF, and DSIF to enable transcription elongation[@zhou2013]. |
| Gene Expression Control | Regulates expression of immediate-early genes, heat shock proteins, and anti-apoptotic genes. |
| Neuronal Survival | Protects neurons from oxidative stress and excitotoxicity through regulation of neurotrophic factor expression. |
| Mitochondrial Function | Regulates expression of mitochondrial genes and proteins involved in energy metabolism. |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, BRD4, DNA, DYRK1A, Fus, GAIN |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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