gene

DYRK1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYRK1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

183Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

DYRK1A gene page - Down syndrome kinase, tau phosphorylation, AD/PD

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🧬 Gene Info

Gene Symbol	DYRK1A
Full Name	Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A
Aliases	DYRK1A gene page, Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome	21q22.13
Protein Type	Serine/Threonine Kinase
Function	The DYRK1A gene encodes Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A, a member of the dual-specificity tyrosine-regulated kinase (DYRK) family.
Primary Expression	individuals with trisomy 21 (Down syndrome)
Molecular Weight	85 kDa
Amino Acids	754 aa
Pathways	Apoptosis, Differentiation
UniProt ID	Q13627
NCBI Gene ID	1785
Ensembl ID	ENSG00000157540
OMIM	600855
GeneCards	DYRK1A
Human Protein Atlas	DYRK1A
Associated Diseases	ALS, Alzheimer, Cancer, Epilepsy, Neurodegeneration
Interactions	NRF2, OPTN, FGFR1, PTEN, PIK3CA, NRAS
KG Connections	183 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYRK1A — AlphaFold Q13627 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DYRK1A["<b>DYRK1A</b>"]
    Ms{"Ms"}
    DYRK1A -->|"regulates"| Ms
    Stroke{"Stroke"}
    DYRK1A -->|"regulates"| Stroke
    Neurodegeneration{"Neurodegeneration"}
    DYRK1A -->|"regulates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    DYRK1A -->|"regulates"| Alzheimer
    SMAC["SMAC"]
    DYRK1A -->|"regulates"| SMAC
    AIF["AIF"]
    DYRK1A -->|"regulates"| AIF
    Apoptosis(["Apoptosis"])
    DYRK1A -->|"regulates"| Apoptosis
    APOPTOSIS["APOPTOSIS"]
    DYRK1A -->|"activates"| APOPTOSIS
    DYRK1A -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    DYRK1A -->|"implicated in"| neurodegeneration
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| DYRK1A
    E2F1["E2F1"]
    E2F1 -->|"regulates"| DYRK1A
    P53["P53"]
    P53 -->|"regulates"| DYRK1A
    MYC["MYC"]
    MYC -->|"regulates"| DYRK1A
    DIABLO["DIABLO"]
    DIABLO -->|"regulates"| DYRK1A
    EGF["EGF"]
    EGF -->|"regulates"| DYRK1A
    ERK1["ERK1"]
    ERK1 -->|"regulates"| DYRK1A
    APOPTOSIS -->|"regulates"| DYRK1A
    MDM2["MDM2"]
    MDM2 -->|"regulates"| DYRK1A
    RAF1["RAF1"]
    RAF1 -->|"regulates"| DYRK1A
    P38["P38"]
    P38 -->|"regulates"| DYRK1A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| DYRK1A
    style DYRK1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (128)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
epileptogenic brain lesions	implicated_in	disease	0.80
DYRK1B	activates	gene	0.70
CRISPR-Cas	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Ms	regulates	disease	0.65
Stroke	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	implicated_in	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Asthma	treats	disease	0.65
Als	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
SMAC	regulates	gene	0.60
AIF	regulates	gene	0.60
P38	regulates	gene	0.60
MDM2	regulates	gene	0.60
EGF	regulates	gene	0.60
DIABLO	regulates	gene	0.60
MYC	regulates	gene	0.60
NRF2	activates	gene	0.60
OPTN	activates	gene	0.60
MTOR	associated_with	gene	0.60
FGFR1	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
NF1	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
EGFR	inhibits	gene	0.60
EGFR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
NF1	interacts_with	gene	0.60
SIRT1	activates	gene	0.60
neurodegeneration	associated_with	disease	0.60
epilepsy	associated_with	disease	0.60
PTPN11	interacts_with	gene	0.60
FOXO1	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60

Incoming (55)

Source	Relation	Type	Str
AKT	interacts_with	gene	0.70
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
EGF	regulates	gene	0.60
ERK1	regulates	gene	0.60
MDM2	regulates	gene	0.60
RAF1	regulates	gene	0.60
P38	regulates	gene	0.60
AIF	regulates	gene	0.60
JNK	regulates	gene	0.60
PINK1	activates	gene	0.60
KEAP1	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
TAU	inhibits	gene	0.60
NRAS	associated_with	gene	0.60
NF1	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
FGFR1	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
BRAF	interacts_with	gene	0.60
CDK9	inhibits	gene	0.60
CTSB	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
P53	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ROS	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
DMSO	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
EPILEPSY	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
ATP	activates	gene	0.60
CRBN	activates	gene	0.60
BRAF	associated_with	gene	0.50
EGFR	interacts_with	gene	0.50
AKT3	interacts_with	protein	0.50
AKT3	co_expressed_with	protein	0.50
BRAF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DYRK1A

Understanding Entity Pages

Summary

Wiki Pages (21)

DYRK1A Gene - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A

Therapeutics

Alzheimer's Disease

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

CBS/PSP Genetic Architecture

Tau Pathology

Urolithin A for Neurodegeneration

cortisol-tau-pathway

4R Tauopathy Mechanisms

MAPT (Microtubule-Associated Protein Tau) Gene

MAPT→Tau→Aggregation→PSP Causal Chain

Tauopathy

PP2A Protein

Tau Post-Translational Modifications in 4R-Tauopathies

LEF1

Frontal Cortex Neurons in Alzheimer's Disease

down-syndrome-alzheimers

DIABLO

levetiracetam-down-syndrome-ad-nct07234695