cell 871 words KG: ent-gene-06beb203 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

IGF-1 Receptor Neurons

🔬 Protein Info
Gene SymbolIGF
Full Name1 Receptor (IGF1R) Neurons
Chromosome15q26.3
Function- Oligodendrocyte survival: Via IGF1R signaling
GeneCardsIGF
Human Protein AtlasIGF
TaxonomyID
Cell Ontology (CL)CL:0000197
LigandAffinity
IGF-1Highest
IGF-2High
InsulinLow
Brain RegionExpression Level
CortexHigh
HippocampusHigh
Associated DiseasesAls, Fibrosis, Aging, Neurodegeneration, Cancer, Amyotrophic Lateral Sclerosis
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (13)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

Related Experiments (4)

In vivo IGF-I intravitreal injection in rd10 mice
validation · proposed · Score: 0.90
Ex vivo IGF-I treatment in rd10 organotypic retinal explants
validation · proposed · Score: 0.90
Microglial depletion study using clodronate liposomes
exploratory · proposed · Score: 0.85
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-06beb203 data_in benchmark_ot_ad_answer_key:IGF1R
benchmark_ot_ad_answer_key:IGF1R data_in ent-gene-06beb203