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Clinical: Theta Deep Brain Stimulation for Cognitive Enhancement in Pa
clinical
1,277 words
KG: OVERVIEW
2026-03-29
section:clinical-trials
kind:clinical-trial
topic:parkinsons
state:published
Contents
Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease (NCT06518824)
Knowledge Graph
Related Hypotheses (25)
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.59
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.75
Blood-Brain Barrier SPM Shuttle System
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Vocal Cord Neuroplasticity Stimulation
Score: 0.72
VCP-Mediated Autophagy Enhancement
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Lysosomal Membrane Repair Enhancement
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.67
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.64
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Show 20 more
Related Analyses (30)
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Show 25 more
Related Experiments (30)
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation
validation · proposed · Score: 0.40
Alpha-Synuclein Seed Amplification Assay Validation
clinical · proposed · Score: 0.40
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Antiviral Therapy Trial for Parkinson's Disease
clinical · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40
Combination Therapy Sequencing in Parkinson's Disease
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Alpha-Synuclein Staging and Spreading in DLB — Spatial Propa
validation · proposed · Score: 0.40
DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40
Mechanism: Selective Vulnerability of Dopaminergic Neurons i
validation · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
GLP-1 Agonist Neuroprotection Mechanism in PD
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechani
clinical · proposed · Score: 0.40
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson
clinical · proposed · Score: 0.40
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
validation · proposed · Score: 0.40
Show 25 more
Knowledge Graph (12 edges)
OVERVIEW
biomarker_for
BRAF
OVERVIEW
biomarker_for
ATRX
OVERVIEW
activates
VALOSIN
OVERVIEW
therapeutic_target
CXCR1
OVERVIEW
regulates
LETM1
OVERVIEW
regulates
MCU
OVERVIEW
activates
CHMP2B
OVERVIEW
activates
TARDBP
OVERVIEW
activates
LC3
OVERVIEW
activates
TBK1
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