gene 557 words KG: IDH1 2026-03-24
kind:genesection:genesstate:published
Contents

IDH1 Gene - Isocitrate Dehydrogenase 1

🧬 Gene Info
Gene SymbolIDH1
Full NameIsocitrate Dehydrogenase 1 (NADP+)
AliasesPage for IDH1 Gene, Page for IDH1 Protein
Chromosome2q33.3
Protein TypeEnzyme
FunctionIDH1 is a NADP+-dependent enzyme localized primarily in the cytosol and peroxisomes.
Molecular Weight47 kDa
PathwaysEpigenetic
UniProt IDO75874
NCBI Gene ID3417
Ensembl IDENSG00000138449
GeneCardsIDH1
Human Protein AtlasIDH1
Associated DiseasesAD, ADH, ALI, AMI, ARM, Aging
InteractionsMTOR, IDH2, VHL, MDM4, MCL1, VEGFA
KG Connections388 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Arginine Methylation Enhancement Therapy
Score: 0.46

Related Analyses (6)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (14)

IDH1 and IDH2 mutation sequencing in CNS and non-CNS tumors
exploratory · proposed · Score: 0.95
Clinical outcome analysis based on IDH mutation status
clinical · proposed · Score: 0.85
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (7)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
CD33 Modulation Therapy for Neurodegeneration
idea · KG edge: therapeutic_target
CALM1 — Calmodulin 1
gene · KG edge: therapeutic_target
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with
ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IDH1 interacts_with IDH2
IDH1 associated_with ASTROCYTOMA
IDH1 associated_with OLIGODENDROGLIOMA
IDH1 regulates ENZYMATIC ACTIVITY
IDH1 associated_with ALPHA-KETOGLUTARATE
IDH1 associated_with REDOX BALANCE
IDH1 regulates ORGAN PHYSIOLOGY
IDH1 associated_with BRAIN TUMOURS
IDH1 inhibits MET
IDH1 associated_with GLIOMA