protein 653 words KG: BRAF 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

B-Raf Protein

🔬 Protein Info
Gene SymbolBRAF
AliasesRAF kinase in MAPK signaling
Chromosome7q34
Protein FamilyRAF serine/threonine kinases
Protein TypeSerine/Threonine Kinase
FunctionBRAF is a serine/threonine-protein kinase that serves as a key intermediate in the RAS-RAF-MEK-ERK signaling cascade.
Subcellular Localizationand substrate accessibility
Molecular Weight84.5 kDa
Amino Acids766 aa
PathwaysMAPK, mapk
UniProt ID[P15056](https://www.uniprot.org/uniprot/P15056)
GeneCardsBRAF
Human Protein AtlasBRAF
Associated DiseasesAD, ALS, AMELOBLASTOMA, Cancer
Known Drugs/Compoundsencorafenib + cetuximab, SORAFENIB, TRAMETINIB, dabrafenib
InteractionsPI3K, ERK1, GNAQ, STX17, GNA11, AKT
KG Connections610 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (29)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (22)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-
gene · KG edge: associated_with
ARAF Gene
gene · KG edge: implicated_in

Knowledge Graph (12 edges)

BRAF associated_with PILOCYTIC_ASTROCYTOMA
BRAF associated_with AMELOBLASTOMA
BRAF associated_with ATRX
BRAF therapeutic_target SMO
BRAF associated_with TERT
BRAF associated_with FUBP1
BRAF associated_with H3F3A
BRAF biomarker_for JUN
BRAF associated_with IDH1
BRAF associated_with CIC