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Disease: Investment Landscape: Alzheimer's Disease
disease
767 words
KG: ent-dise-789b2442
2026-03-25
kind:disease
section:diseases
state:published
Contents
Investment Landscape: Alzheimer's Disease
Disease Info
PHASE1
480
PHASE1, PHASE2
113
PHASE2
636
PHASE2, PHASE3
68
PHASE3
321
PHASE4
168
NA
2082
Not Applicable
970
RECRUITING
741
ACTIVE_NOT_RECRUITING
200
NOT_YET_RECRUITING
267
COMPLETED
2529
Databases
OMIM
Orphanet
ClinicalTrials
PubMed
Knowledge Graph
Related Hypotheses (28)
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.71
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.46
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
VCP-Mediated Autophagy Enhancement
Score: 0.41
Extracellular Vesicle Biogenesis Modulation
Score: 0.34
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
TREM2-Dependent Microglial Senescence Transition
Score: 0.74
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
APOE-TREM2 Interaction Modulation
Score: 0.48
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Show 23 more
Related Analyses (24)
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Gut-Brain Axis Therapeutics for AD
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed
Show 19 more
Related Experiments (30)
Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
SPP1-mediated microglial synaptic engulfment assay
exploratory · proposed · Score: 0.95
GWAS of plasma NfL in East Asian cohort
exploratory · proposed · Score: 0.95
Meta-analysis of LRP1 C766T polymorphism and Alzheimer's dis
exploratory · proposed · Score: 0.95
Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95
GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95
Dairy intake and dementia risk in Malmö Diet and Cancer coho
clinical · proposed · Score: 0.95
Real-world safety study of Lecanemab in Japanese AD patients
clinical · proposed · Score: 0.95
GWAS of plasma pTau181 in East Asian cohort
exploratory · proposed · Score: 0.95
Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95
GWAS of plasma GFAP in East Asian cohort
exploratory · proposed · Score: 0.95
Meta-analysis of physical activity interventions on cognitiv
clinical · proposed · Score: 0.95
KEEPS Continuation: Long-term effects of menopausal hormone
clinical · proposed · Score: 0.95
Anti-ASC antibody intracerebroventricular injection in APP/P
validation · proposed · Score: 0.95
Curcumin-Licorice Combination in D-galactose/Sodium Nitrite
validation · proposed · Score: 0.95
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
Endothelial CD2AP knockdown effects on memory in male mice
validation · proposed · Score: 0.90
GWAS of composite biomarker score
exploratory · proposed · Score: 0.90
SPP1 upregulation in perivascular cells in AD mouse models
exploratory · proposed · Score: 0.90
PH-PS treatment in 5×FAD Alzheimer's disease mice
validation · proposed · Score: 0.90
SIRPα modulation in mouse models of Alzheimer's disease
validation · proposed · Score: 0.90
Spp1 knockout prevents synaptic loss in AD mouse models
validation · proposed · Score: 0.90
Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90
Diosmin cognitive rescue in APP/PS1 mice
validation · proposed · Score: 0.90
Tet2 modulation in Aβ42-injured mouse hippocampal neurons
exploratory · proposed · Score: 0.90
Behavioral assessment of APP/PSEN1/GD3S triple-mutant mice
validation · proposed · Score: 0.90
Immunofluorescence analysis of cerebral microvascular densit
exploratory · proposed · Score: 0.90
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice
validation · proposed · Score: 0.90
Show 25 more
See Also (15)
Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 20 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses
Sporadic Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses
Sleep and Circadian Dysfunction in Alzheimer's Disease
mechanism · Pages share 21 hypotheses
Sex-Specific Mechanisms in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
NLRP3 Inflammasome Pathway in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Neurovascular Dysfunction in Alzheimer's Disease: Integ
mechanism · Pages share 18 hypotheses
Neuroinflammation Hypothesis in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Neuroinflammation in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Mitochondrial Dysfunction in Alzheimer's Disease Pathwa
mechanism · Pages share 18 hypotheses
Metal Ion Homeostasis in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Locus Coeruleus Degeneration in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Show 10 more