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Home / Wiki / Entity: Excitotoxicity

entity 1,922 words KG: excitotoxicity 2026-03-24

kind:entity section:entities state:published

Contents

Excitotoxicity

Knowledge Graph

Related Hypotheses (30)

Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa
Score: 0.70 p38α Inhibitor and PRMT1 Activator Combination to Restore Ph
Score: 0.61 Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61 Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli
Score: 0.60 Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57 Optogenetic restoration of hippocampal gamma oscillations vi
Score: 0.57 Purinergic Signaling Polarization Control
Score: 0.55 Thalamocortical Synchrony Restoration via NMDA Modulation
Score: 0.54 Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles
Score: 0.53 Layer V excitatory neurons show selectively enhanced vulnera
Score: 0.51 Ganglioside Rebalancing Therapy
Score: 0.50 cGAS-STING Senescence Circuit Disruption
Score: 0.49 Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48 TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47 Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47 Arginine Methylation Enhancement Therapy
Score: 0.46 Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto
Score: 0.45 CaMKII-Dependent Synaptic Circuit Amplification
Score: 0.44 Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.42 FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39 Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.38 ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66 Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 CYP46A1 Overexpression Gene Therapy
Score: 0.63 Multi-Modal Stress Response Harmonization
Score: 0.60 Microbial Inflammasome Priming Prevention
Score: 0.58 PARP1 Inhibition Therapy
Score: 0.58 Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (18)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived Synaptic pruning by microglia in early AD
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Epigenetic reprogramming in aging neurons
neurodegeneration · archived Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived Mitochondrial transfer between neurons and glia
neurodegeneration · archived SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: associated_with Alzheimer Indonesia
institution · KG edge: activates STIM1 — Stromal Interaction Molecule 1
gene · KG edge: activates SST Gene
gene · KG edge: activates MTOR Gene
gene · KG edge: debate_co_mention

MMP9 Gene
gene · KG edge: debate_co_mention MCU Gene
gene · KG edge: debate_co_mention MAP6 Gene
gene · KG edge: debate_co_mention HK2
gene · KG edge: activates HCRTR1
gene · KG edge: debate_co_mention HCN1 Gene
gene · KG edge: debate_co_mention ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: debate_co_mention GFAP (Redirect)
redirect · KG edge: debate_co_mention

Knowledge Graph (12 edges)

excitotoxicity associated_with Amyotrophic lateral sclerosis

excitotoxicity activates STIM1

excitotoxicity co_mentioned neuroinflammation

excitotoxicity co_mentioned ferroptosis

excitotoxicity associated_with neuroinflammation

excitotoxicity activates SST

excitotoxicity associated_with MIRO1

excitotoxicity co_mentioned MIRO1

excitotoxicity associated_with TRKB

excitotoxicity activates HK2

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