gene 765 words KG: HCRTR1 2026-03-16
kind:genesection:genesstate:published
Contents

HCRTR1

🧬 Gene Info
Gene SymbolHCRT1
Full NameHCRTR1
Protein TypeGene
FunctionThe HCRT1 (Hypocretin/Orexin 1) gene encodes the orexin-A neuropeptide, a critical regulator of arousal, wakefulness, and energy homeostasis
Amino Acids33 aa
PathwaysSleep-Wake Regulation
NCBI Gene IDSearch NCBI
GeneCardsHCRT1
Human Protein AtlasHCRT1
Associated DiseasesALS, Narcolepsy, Sleep Disorder
InteractionsOXR1
KG Connections21 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (17)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.45
Orexin-Microglia Modulation Therapy
Score: 0.49
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59

Related Analyses (5)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · completed

Related Experiments (5)

CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
NPH Glymphatic System Interaction Experiment
clinical · proposed · Score: 0.46
Sleep and Respiratory Network Interaction in ALS — Experimen
clinical · proposed · Score: 0.46
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.46
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.46

See Also (10)

Alzheimer Indonesia
institution · KG edge: regulates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
AQP1 Gene
gene · KG edge: co_discussed
adra2b Gene
gene · KG edge: expressed_in
ADRA1B — Alpha-1B Adrenergic Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

HCRTR1 associated_with neurodegeneration
HCRTR1 interacts_with HCRTR2
HCRTR1 co_discussed AQP4
HCRTR1 co_discussed LOX
HCRTR1 co_discussed SDC1
HCRTR1 co_discussed PDGFRB
HCRTR1 therapeutic_target TRPC6
HCRTR1 regulates HCRTR2
HCRTR1 therapeutic_target HCRTR2
HCRTR1 therapeutic_target PNOC