| Gene Symbol | HCN1 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | HCN1 is a cyclic nucleotide-gated channel with unique properties |
| Mechanism of Action | HCN1 encodes a hyperpolarization-activated cyclic nucleotide-gated channel critical for neuronal pacemaking and synaptic integration, with dysregulation linked to hyperexcitability disorders and potential neurodegeneration mechanisms. Specifically, HCN1 channel dysfunction can alter neuronal excitability, synaptic plasticity, and potentially contribute to neuronal death or dysfunction in conditions like epilepsy and neurodegenerative diseases. |
| Subcellular Localization | Dendritic shafts, dendritic spines, axon initial segment |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Pathways | HCN1-Mediated Resonance Frequency Stabilization Th, Scotopic Pathway |
| UniProt ID | A0A0U1RQR7 |
| GeneCards | HCN1 |
| Human Protein Atlas | HCN1 |
| Region | Expression Level |
| [Cortex](/brain-regions/cortex) (Layer 5) | High |
| Hippocampus CA1 | High |
| Associated Diseases | AD, ALI, ALS, AMI, ARM, Absence Seizures |
| Known Drugs/Compounds | Propofol, ketamine, Zd7288, propofol |
| Interactions | HCN2, JUN, NPY, KCNH2, NEURODEGENERATION, AND |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HCN1-Selective Blockade Normalizes Thalamic Reboun HCN1-Mediated Resonance Frequency Stabilization Th |
| KG Connections | 344 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |